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dc.contributor.authorBrönstrup, Mark
dc.contributor.authorSasse, Florenz
dc.date.accessioned2021-05-28T13:37:29Z
dc.date.available2021-05-28T13:37:29Z
dc.date.issued2020-05-19
dc.identifier.citationNat Prod Rep. 2020 Jun 24;37(6):752-762. doi: 10.1039/d0np00011f.en_US
dc.identifier.pmid32428051
dc.identifier.doi10.1039/d0np00011f
dc.identifier.urihttp://hdl.handle.net/10033/622887
dc.description.abstractCovering: 2000 to 2020 The translation of mRNA into proteins is a precisely regulated, complex process that can be divided into three main stages, i.e. initiation, elongation, termination, and recycling. This contribution is intended to highlight how natural products interfere with the elongation phase of eukaryotic protein biosynthesis. Cycloheximide, isolated from Streptomyces griseus, has long been the prototype inhibitor of eukaryotic translation elongation. In the last three decades, a variety of natural products from different origins were discovered to also address the elongation step in different manners, including interference with the elongation factors eEF1 and eEF2 as well as binding to A-, P- or E-sites of the ribosome itself. Recent advances in the crystallization of the ribosomal machinery together with natural product inhibitors allowed characterizing similarities as well as differences in their mode of action. Since aberrations in protein synthesis are commonly observed in tumors, and malfunction or overexpression of translation factors can cause cellular transformation, the protein synthesis machinery has been realized as an attractive target for anticancer drugs. The therapeutic use of the first natural products that reached market approval, plitidepsin (Aplidin®) and homoharringtonine (Synribo®), will be introduced. In addition, we will highlight two other potential indications for translation elongation inhibitors, i.e. viral infections and genetic disorders caused by premature termination of translation.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleNatural products targeting the elongation phase of eukaryotic protein biosynthesis.en_US
dc.typeArticleen_US
dc.identifier.eissn1460-4752
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalNatural product reportsen_US
dc.source.volume37
dc.source.issue6
dc.source.beginpage752
dc.source.endpage762
refterms.dateFOA2021-05-19T00:00:00Z
dc.source.journaltitleNatural product reports
dc.source.countryEngland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International