Leader peptide exchange to produce hybrid, new-to-nature ribosomal natural products.

Franz, Laura; Koehnke, Jesko

dc.contributor.author	Franz, Laura
dc.contributor.author	Koehnke, Jesko
dc.date.accessioned	2021-06-25T13:56:40Z
dc.date.available	2021-06-25T13:56:40Z
dc.date.issued	2021-05-24
dc.identifier.citation	Chem Commun (Camb). 2021 Jun 2. doi: 10.1039/d0cc06889f. Epub ahead of print.	en_US
dc.identifier.pmid	34075907
dc.identifier.doi	10.1039/d0cc06889f
dc.identifier.uri	http://hdl.handle.net/10033/622912
dc.description.abstract	Ribosomal natural products contain exquisite post-translational peptide modifications that are installed by a range of pathway-specific enzymes. We present proof of principle for a Sortase A-based approach that enables peptide modification by enzymes from unrelated pathways. This allowed the one-pot synthesis of a new-to-nature, hybrid ribosomal natural product.	en_US
dc.language.iso	en	en_US
dc.publisher	RSC	en_US
dc.rights	Attribution-NonCommercial 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	*
dc.title	Leader peptide exchange to produce hybrid, new-to-nature ribosomal natural products.	en_US
dc.type	Article	en_US
dc.identifier.eissn	1364-548X
dc.contributor.department	HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.	en_US
dc.identifier.journal	Chemical communications (Cambridge, England)	en_US
refterms.dateFOA	2021-06-25T13:56:41Z
dc.source.journaltitle	Chemical communications (Cambridge, England)
dc.source.country	England