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dc.contributor.authorFranz, Sergej
dc.contributor.authorPott, Fabian
dc.contributor.authorZillinger, Thomas
dc.contributor.authorSchüler, Christiane
dc.contributor.authorDapa, Sandra
dc.contributor.authorFischer, Carlo
dc.contributor.authorPassos, Vânia
dc.contributor.authorStenzel, Saskia
dc.contributor.authorChen, Fangfang
dc.contributor.authorDöhner, Katinka
dc.contributor.authorHartmann, Gunther
dc.contributor.authorSodeik, Beate
dc.contributor.authorPessler, Frank
dc.contributor.authorSimmons, Graham
dc.contributor.authorDrexler, Jan Felix
dc.contributor.authorGoffinet, Christine
dc.date.accessioned2021-07-01T13:26:04Z
dc.date.available2021-07-01T13:26:04Z
dc.date.issued2021-06-02
dc.identifier.citationLife Sci Alliance. 2021 Jun 2;4(7):e202000909. doi: 10.26508/lsa.202000909.en_US
dc.identifier.pmid34078739
dc.identifier.doi10.26508/lsa.202000909
dc.identifier.urihttp://hdl.handle.net/10033/622918
dc.description.abstractInterferon-induced transmembrane (IFITM) proteins restrict membrane fusion and virion internalization of several enveloped viruses. The role of IFITM proteins during alphaviral infection of human cells and viral counteraction strategies are insufficiently understood. Here, we characterized the impact of human IFITMs on the entry and spread of chikungunya virus and Mayaro virus and provide first evidence for a CHIKV-mediated antagonism of IFITMs. IFITM1, 2, and 3 restricted infection at the level of alphavirus glycoprotein-mediated entry, both in the context of direct infection and cell-to-cell transmission. Relocalization of normally endosomal IFITM3 to the plasma membrane resulted in loss of antiviral activity. rs12252-C, a naturally occurring variant of IFITM3 that may associate with severe influenza in humans, restricted CHIKV, MAYV, and influenza A virus infection as efficiently as wild-type IFITM3 Antivirally active IFITM variants displayed reduced cell surface levels in CHIKV-infected cells involving a posttranscriptional process mediated by one or several nonstructural protein(s) of CHIKV. Finally, IFITM3-imposed reduction of specific infectivity of nascent particles provides a rationale for the necessity of a virus-encoded counteraction strategy against this restriction factor.en_US
dc.language.isoenen_US
dc.publisherLife Science Allianceen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleHuman IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction.en_US
dc.typeArticleen_US
dc.identifier.eissn2575-1077
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalLife science allianceen_US
dc.source.volume4
dc.source.issue7
refterms.dateFOA2021-07-01T13:26:04Z
dc.source.journaltitleLife science alliance
dc.source.countryUnited States


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International