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dc.contributor.authorAbd El Ghany, Moataz
dc.contributor.authorBarquist, Lars
dc.contributor.authorClare, Simon
dc.contributor.authorBrandt, Cordelia
dc.contributor.authorMayho, Matthew
dc.contributor.authorJoffre, Enrique
dc.contributor.authorSjöling, Åsa
dc.contributor.authorTurner, A Keith
dc.contributor.authorKlena, John D
dc.contributor.authorKingsley, Robert A
dc.contributor.authorHill-Cawthorne, Grant A
dc.contributor.authorDougan, Gordon
dc.contributor.authorPickard, Derek
dc.date.accessioned2021-07-01T14:44:59Z
dc.date.available2021-07-01T14:44:59Z
dc.identifier.citationMicrob Genom. 2021 Jun;7(6). doi: 10.1099/mgen.0.000554.en_US
dc.identifier.pmid34110281
dc.identifier.doi10.1099/mgen.0.000554
dc.identifier.urihttp://hdl.handle.net/10033/622920
dc.description.abstractEnterotoxigenic Escherichia coli (ETEC) expressing the colonization pili CFA/I are common causes of diarrhoeal infections in humans. Here, we use a combination of transposon mutagenesis and transcriptomic analysis to identify genes and pathways that contribute to ETEC persistence in water environments and colonization of a mammalian host. ETEC persisting in water exhibit a distinct RNA expression profile from those growing in richer media. Multiple pathways were identified that contribute to water survival, including lipopolysaccharide biosynthesis and stress response regulons. The analysis also indicated that ETEC growing in vivo in mice encounter a bottleneck driving down the diversity of colonizing ETEC populations.en_US
dc.language.isoenen_US
dc.publisherMicrobiology Societyen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCFA/Ien_US
dc.subjectETECen_US
dc.subjectH10407en_US
dc.subjectRNAseqen_US
dc.subjectTraDISen_US
dc.subjectwater survival and colonizationen_US
dc.titleFunctional analysis of colonization factor antigen I positive enterotoxigenic identifies genes implicated in survival in water and host colonization.en_US
dc.typeArticleen_US
dc.identifier.eissn2057-5858
dc.contributor.departmentHIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.en_US
dc.identifier.journalMicrobial genomicsen_US
dc.source.volume7
dc.source.issue6
refterms.dateFOA2021-07-01T14:45:00Z
dc.source.journaltitleMicrobial genomics
dc.source.countryEngland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International