• Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.

      Marandu, Thomas F; Oduro, Jennifer D; Borkner, Lisa; Dekhtiarenko, Iryna; Uhrlaub, Jennifer L; Drabig, Anja; Kröger, Andrea; Nikolich-Zugich, Janko; Cicin-Sain, Luka; Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany. (2015-11-15)
      Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients.