• Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice.

      Kurhade, Chaitanya; Schreier, Sarah; Lee, Yi-Ping; Zegenhagen, Loreen; Hjertqvist, Marika; Dobler, Gerhard; Kröger, Andrea; Överby, Anna K; HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany. (2018-09-01)
      We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis