Mastering the Gram-negative bacterial barrier - Chemical approaches to increase bacterial bioavailability of antibiotics.
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Issue Date
2021-03-08
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Show full item recordAbstract
To win the battle against resistant, pathogenic bacteria, novel classes of anti-infectives and targets are urgently needed. Bacterial uptake, distribution, metabolic and efflux pathways of antibiotics in Gram-negative bacteria determine what we here refer to as bacterial bioavailability. Understanding these mechanisms from a chemical perspective is essential for anti-infective activity and hence, drug discovery as well as drug delivery. A systematic and critical discussion of in bacterio, in vitro and in silico assays reveals that a sufficiently accurate holistic approach is still missing. We expect new findings based on Gram-negative bacterial bioavailability to guide future anti-infective research.Citation
Adv Drug Deliv Rev. 2021 May;172:339-360. doi: 10.1016/j.addr.2021.02.014. Epub 2021 Mar 8.Affiliation
HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.Publisher
ElsevierJournal
Advanced drug delivery reviewsPubMed ID
33705882Type
ReviewLanguage
enEISSN
1872-8294ae974a485f413a2113503eed53cd6c53
10.1016/j.addr.2021.02.014
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