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dc.contributor.authorRopponen, Henni-Karoliina
dc.contributor.authorRichter, Robert
dc.contributor.authorHirsch, Anna K H
dc.contributor.authorLehr, Claus Michael
dc.date.accessioned2021-07-26T11:30:53Z
dc.date.available2021-07-26T11:30:53Z
dc.date.issued2021-03-08
dc.identifier.citationAdv Drug Deliv Rev. 2021 May;172:339-360. doi: 10.1016/j.addr.2021.02.014. Epub 2021 Mar 8.en_US
dc.identifier.pmid33705882
dc.identifier.doi10.1016/j.addr.2021.02.014
dc.identifier.urihttp://hdl.handle.net/10033/622960
dc.description.abstractTo win the battle against resistant, pathogenic bacteria, novel classes of anti-infectives and targets are urgently needed. Bacterial uptake, distribution, metabolic and efflux pathways of antibiotics in Gram-negative bacteria determine what we here refer to as bacterial bioavailability. Understanding these mechanisms from a chemical perspective is essential for anti-infective activity and hence, drug discovery as well as drug delivery. A systematic and critical discussion of in bacterio, in vitro and in silico assays reveals that a sufficiently accurate holistic approach is still missing. We expect new findings based on Gram-negative bacterial bioavailability to guide future anti-infective research.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAccumulation rulesen_US
dc.subjectAntibiotic drug design & discoveryen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectDrug deliveryen_US
dc.subjectIn silico &in vitro assaysen_US
dc.subjectMedicinal chemistryen_US
dc.subjectPermeabilityen_US
dc.titleMastering the Gram-negative bacterial barrier - Chemical approaches to increase bacterial bioavailability of antibiotics.en_US
dc.typeReviewen_US
dc.identifier.eissn1872-8294
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalAdvanced drug delivery reviewsen_US
dc.source.volume172
dc.source.beginpage339
dc.source.endpage360
dc.source.journaltitleAdvanced drug delivery reviews
dc.source.countryNetherlands


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