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dc.contributor.authorSchmidt, Nora
dc.contributor.authorMunschauer, Mathias
dc.date.accessioned2021-07-28T09:19:26Z
dc.date.available2021-07-28T09:19:26Z
dc.date.issued2021-06-26
dc.identifier.citationBiospektrum 27, 376–379 (2021). https://doi.org/10.1007/s12268-021-1587-3.en_US
dc.identifier.issn0947-0867
dc.identifier.pmid34219983
dc.identifier.doi10.1007/s12268-021-1587-3
dc.identifier.urihttp://hdl.handle.net/10033/622963
dc.description.abstractUsing RNA antisense purification and mass spectrometry, we identified more than 100 human proteins that directly and specifically bind SARS-CoV-2 RNA in infected cells. To gain insights into the functions of selected RNA interactors, we applied genetic perturbation and pharmacological inhibition experiments, and mapped the contact sites on the viral RNA. This led to the identification of host dependency factors and defense strategies, which can guide the design of novel therapeutics against SARS-CoV-2.en_US
dc.language.isodeen_US
dc.publisherSpringeren_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleAtlas der SARS-CoV-2-RNA-Protein-Interaktionen in infizierten Zellenen_US
dc.typeReviewen_US
dc.contributor.departmentHIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.en_US
dc.identifier.journalBiospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)en_US
dc.source.volume27
dc.source.issue4
dc.source.beginpage376
dc.source.endpage379
refterms.dateFOA2021-07-28T09:19:26Z
dc.source.journaltitleBiospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)
dc.source.countryGermany


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International