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dc.contributor.authorHerrmann, Inge Katrin
dc.contributor.authorWood, Matthew John Andrew
dc.contributor.authorFuhrmann, Gregor
dc.date.accessioned2021-07-28T15:16:37Z
dc.date.available2021-07-28T15:16:37Z
dc.date.issued2021-07-01
dc.identifier.citation(2021).Nature Nanotechnology, 16(7), 748-759. doi:10.1038/s41565-021-00931-2.en_US
dc.identifier.pmid34211166
dc.identifier.doi10.1038/s41565-021-00931-2
dc.identifier.urihttp://hdl.handle.net/10033/622966
dc.description.abstractExtracellular-vesicle-based cell-to-cell communication is conserved across all kingdoms of life. There is compelling evidence that extracellular vesicles are involved in major (patho)physiological processes, including cellular homoeostasis, infection propagation, cancer development and cardiovascular diseases. Various studies suggest that extracellular vesicles have several advantages over conventional synthetic carriers, opening new frontiers for modern drug delivery. Despite extensive research, clinical translation of extracellular-vesicle-based therapies remains challenging. Here, we discuss the uniqueness of extracellular vesicles along with critical design and development steps required to utilize their full potential as drug carriers, including loading methods, in-depth characterization and large-scale manufacturing. We compare the prospects of extracellular vesicles with those of the well established liposomes and provide guidelines to direct the process of developing vesicle-based drug delivery systems.en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleExtracellular vesicles as a next-generation drug delivery platform.en_US
dc.typeReviewen_US
dc.identifier.eissn1748-3395
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalNature nanotechnologyen_US
dc.source.volume16
dc.source.issue7
dc.source.beginpage748
dc.source.endpage759
dc.source.journaltitleNature nanotechnology
dc.source.countryEngland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International