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dc.contributor.authorSingh, Bhumika
dc.contributor.authorAbdelgawad, Mohamed Essameldin
dc.contributor.authorAli, Zulfiqur
dc.contributor.authorBailey, Jarrod
dc.contributor.authorBudyn, Elisa
dc.contributor.authorCivita, Prospero
dc.contributor.authorClift, Martin J D
dc.contributor.authorConnelly, John T
dc.contributor.authorConstant, Samuel
dc.contributor.authorHittinger, Marius
dc.contributor.authorKandarova, Helena
dc.contributor.authorKearns, Victoria Rosalind
dc.contributor.authorKiuru, Tony
dc.contributor.authorKostrzewski, Tomasz
dc.contributor.authorKress, Sebastian
dc.contributor.authorDurban, Victoria Marsh
dc.contributor.authorLehr, Claus-Michael
dc.contributor.authorMcMillan, Hayley
dc.contributor.authorMetz, Julia Katharina
dc.contributor.authorMonteban, Vivian
dc.contributor.authorMovia, Dania
dc.contributor.authorNeto, Catia
dc.contributor.authorOwen, Carla
dc.contributor.authorPaasonen, Lauri
dc.contributor.authorPalmer, Kerri Anne
dc.contributor.authorPilkington, Geoffrey John
dc.contributor.authorPilkington, Karen
dc.contributor.authorPrina-Mello, Adriele
dc.contributor.authorRoper, Clive
dc.contributor.authorSheard, Jonathan
dc.contributor.authorSmith, Sheree
dc.contributor.authorTurner, Janette Ellen
dc.contributor.authorRoy, Ipsita
dc.contributor.authorTutty, Melissa Anne
dc.contributor.authorVelliou, Eirini
dc.contributor.authorWilkinson, John Malcolm
dc.identifier.citationAltern Lab Anim. 2021 Jul 6:2611929211025006. doi: 10.1177/02611929211025006. Epub ahead of print.en_US
dc.description.abstractExperimental systems that faithfully replicate human physiology at cellular, tissue and organ level are crucial to the development of efficacious and safe therapies with high success rates and low cost. The development of such systems is challenging and requires skills, expertise and inputs from a diverse range of experts, such as biologists, physicists, engineers, clinicians and regulatory bodies. Kirkstall Limited, a biotechnology company based in York, UK, organised the annual conference, Advances in Cell and Tissue Culture (ACTC), which brought together people having a variety of expertise and interests, to present and discuss the latest developments in the field of cell and tissue culture and in vitro modelling. The conference has also been influential in engaging animal welfare organisations in the promotion of research, collaborative projects and funding opportunities. This report describes the proceedings of the latest ACTC conference, which was held virtually on 30th September and 1st October 2020, and included sessions on in vitro models in the following areas: advanced skin and respiratory models, neurological disease, cancer research, advanced models including 3-D, fluid flow and co-cultures, diabetes and other age-related disorders, and animal-free research. The roundtable session on the second day was very interactive and drew huge interest, with intriguing discussion taking place among all participants on the theme of replacement of animal models of disease.en_US
dc.publisherFund for the Replacement of Animals in Medical Experiments (FRAME)en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.subjectThree Rsen_US
dc.subjectanimal replacementen_US
dc.subjectin vitroen_US
dc.subjectmicrophysiological systemen_US
dc.subjectnew approach methodologiesen_US
dc.subjecttissue microenvironmenten_US
dc.titleTowards More Predictive, Physiological and Animal-free in vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings.en_US
dc.typeconference proceedingsen_US
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalAlternatives to laboratory animals : ATLAen_US
dc.rights.holderReuse is restricted to non-commercial and no derivative uses
dc.source.journaltitleAlternatives to laboratory animals : ATLA

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Attribution-NonCommercial-NoDerivatives 4.0 International
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