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dc.contributor.authorElfstrand, Malin
dc.contributor.authorChen, Jun
dc.contributor.authorCleary, Michelle
dc.contributor.authorHalecker, Sandra
dc.contributor.authorIhrmark, Katarina
dc.contributor.authorKarlsson, Magnus
dc.contributor.authorDavydenko, Kateryna
dc.contributor.authorStenlid, Jan
dc.contributor.authorStadler, Marc
dc.contributor.authorDurling, Mikael Brandström
dc.date.accessioned2021-07-30T12:47:44Z
dc.date.available2021-07-30T12:47:44Z
dc.date.issued2021-07-04
dc.identifier.citationBMC Genomics. 2021 Jul 4;22(1):503. doi: 10.1186/s12864-021-07837-2.en_US
dc.identifier.pmid34217229
dc.identifier.doi10.1186/s12864-021-07837-2
dc.identifier.urihttp://hdl.handle.net/10033/622973
dc.description.abstractBackground: The dieback epidemic decimating common ash (Fraxinus excelsior) in Europe is caused by the invasive fungus Hymenoscyphus fraxineus. In this study we analyzed the genomes of H. fraxineus and H. albidus, its native but, now essentially displaced, non-pathogenic sister species, and compared them with several other members of Helotiales. The focus of the analyses was to identify signals in the genome that may explain the rapid establishment of H. fraxineus and displacement of H. albidus. Results: The genomes of H. fraxineus and H. albidus showed a high level of synteny and identity. The assembly of H. fraxineus is 13 Mb longer than that of H. albidus', most of this difference can be attributed to higher dispersed repeat content (i.e. transposable elements [TEs]) in H. fraxineus. In general, TE families in H. fraxineus showed more signals of repeat-induced point mutations (RIP) than in H. albidus, especially in Long-terminal repeat (LTR)/Copia and LTR/Gypsy elements. Comparing gene family expansions and 1:1 orthologs, relatively few genes show signs of positive selection between species. However, several of those did appeared to be associated with secondary metabolite genes families, including gene families containing two of the genes in the H. fraxineus-specific, hymenosetin biosynthetic gene cluster (BGC). Conclusion: The genomes of H. fraxineus and H. albidus show a high degree of synteny, and are rich in both TEs and BGCs, but the genomic signatures also indicated that H. albidus may be less well equipped to adapt and maintain its ecological niche in a rapidly changing environment.en_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAsh diebacken_US
dc.subjectFraxinus excelsioren_US
dc.subjectSecondary metabolitesen_US
dc.subjectTransposable elementsen_US
dc.subjectViridiolen_US
dc.subjectinvasive speciesen_US
dc.titleComparative analyses of the Hymenoscyphus fraxineus and Hymenoscyphus albidus genomes reveals potentially adaptive differences in secondary metabolite and transposable element repertoires.en_US
dc.typeArticleen_US
dc.identifier.eissn1471-2164
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalBMC genomicsen_US
dc.source.volume22
dc.source.issue1
dc.source.beginpage503
dc.source.endpage
refterms.dateFOA2021-07-30T12:47:45Z
dc.source.journaltitleBMC genomics
dc.source.countryEngland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International