Novel Fredericamycin Variant Overproduced by a Streptomycin-resistant subsp. Strain.
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Rodríguez Estévez et al.pdf
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Authors
Rodríguez Estévez, MartaMyronovskyi, Maksym
Rosenkränzer, Birgit
Paululat, Thomas
Petzke, Lutz
Ristau, Jeanette
Luzhetskyy, Andriy
Issue Date
2020-05-28
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Show full item recordAbstract
Streptomycetes are an important source of natural products potentially applicable in the pharmaceutical industry. Many of these drugs are secondary metabolites whose biosynthetic genes are very often poorly expressed under laboratory cultivation conditions. In many cases, antibiotic-resistant mutants exhibit increased production of natural drugs, which facilitates the identification and isolation of new substances. In this study, we report the induction of a type II polyketide synthase gene cluster in the marine strain Streptomyces albus subsp. chlorinus through the selection of streptomycin-resistant mutants, resulting in overproduction of the novel compound fredericamycin C2 (1). Fredericamycin C2 (1) is structurally related to the potent antitumor drug lead fredericamycin A.Citation
Mar Drugs. 2020 May 28;18(6):284. doi: 10.3390/md18060284.Affiliation
HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.Publisher
MDPIJournal
Marine drugsPubMed ID
32481766Type
ArticleLanguage
enEISSN
1660-3397ae974a485f413a2113503eed53cd6c53
10.3390/md18060284
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- Creative Commons
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