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dc.contributor.authorRodríguez Estévez, Marta
dc.contributor.authorMyronovskyi, Maksym
dc.contributor.authorRosenkränzer, Birgit
dc.contributor.authorPaululat, Thomas
dc.contributor.authorPetzke, Lutz
dc.contributor.authorRistau, Jeanette
dc.contributor.authorLuzhetskyy, Andriy
dc.date.accessioned2021-08-06T09:57:28Z
dc.date.available2021-08-06T09:57:28Z
dc.date.issued2020-05-28
dc.identifier.citationMar Drugs. 2020 May 28;18(6):284. doi: 10.3390/md18060284.en_US
dc.identifier.pmid32481766
dc.identifier.doi10.3390/md18060284
dc.identifier.urihttp://hdl.handle.net/10033/622982
dc.description.abstractStreptomycetes are an important source of natural products potentially applicable in the pharmaceutical industry. Many of these drugs are secondary metabolites whose biosynthetic genes are very often poorly expressed under laboratory cultivation conditions. In many cases, antibiotic-resistant mutants exhibit increased production of natural drugs, which facilitates the identification and isolation of new substances. In this study, we report the induction of a type II polyketide synthase gene cluster in the marine strain Streptomyces albus subsp. chlorinus through the selection of streptomycin-resistant mutants, resulting in overproduction of the novel compound fredericamycin C2 (1). Fredericamycin C2 (1) is structurally related to the potent antitumor drug lead fredericamycin A.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectantitumoren_US
dc.subjectfredericamycinen_US
dc.subjectoverproductionen_US
dc.subjectsecondary metabolitesen_US
dc.subjectstreptomycetesen_US
dc.subjectstreptomycin-resistanten_US
dc.subjecttype II PKSen_US
dc.titleNovel Fredericamycin Variant Overproduced by a Streptomycin-resistant subsp. Strain.en_US
dc.typeArticleen_US
dc.identifier.eissn1660-3397
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalMarine drugsen_US
dc.source.volume18
dc.source.issue6
refterms.dateFOA2021-08-06T09:57:29Z
dc.source.journaltitleMarine drugs
dc.source.countrySwitzerland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International