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dc.contributor.authorKhodamoradi, Shadi
dc.contributor.authorStadler, Marc
dc.contributor.authorWink, Joachim
dc.contributor.authorSurup, Frank
dc.date.accessioned2021-08-06T10:13:00Z
dc.date.available2021-08-06T10:13:00Z
dc.date.issued2020-05-26
dc.identifier.citationMar Drugs. 2020 May 26;18(6):280. doi: 10.3390/md18060280.en_US
dc.identifier.pmid32466459
dc.identifier.doi10.3390/md18060280
dc.identifier.urihttp://hdl.handle.net/10033/622983
dc.description.abstractStreptomonospora sp. M2 has been isolated from a soil sample collected at the Wadden Sea beach in our ongoing program aimed at the isolation of rare Actinobacteria, ultimately targeting the discovery of new antibiotics. Because crude extracts derived from cultures of this strain showed inhibitory activity against the indicator organism Bacillus subtilis, it was selected for further analysis. HPLC-MS analysis of its culture broth revealed the presence of lipophilic metabolites. The two major metabolites of those were isolated by preparative reversed-phase HPLC and preparative TLC. Their planar structures were elucidated using high-resolution electrospray ionization mass spectrometry (HRESIMS), 1D and 2D NMR data as new thiopeptide antibiotics and named litoralimycin A (1) and B (2). Although rotating frame nuclear Overhauser effect spectroscopy (ROESY) data established a Z configuration of the Δ21,26 double bond, the stereochemistry of C-5 and C-15 were assigned as S by Marfey's method after ozonolysis. The biological activity spectrum of 1 and 2 is highly uncommon for thiopeptide antibiotics, since they showed only insignificant antibacterial activity, but 1 showed strong cytotoxic effects.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectnatural productsen_US
dc.subjectrare actinobacteriaen_US
dc.subjectscreeningen_US
dc.subjectstructure elucidationen_US
dc.subjectthiopeptide antibioticen_US
dc.titleLitoralimycins A and B, New Cytotoxic Thiopeptides from Streptomonospora sp. M2.en_US
dc.typeArticleen_US
dc.identifier.eissn1660-3397
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalMarine drugsen_US
dc.source.volume18
dc.source.issue6
refterms.dateFOA2021-08-06T10:13:01Z
dc.source.journaltitleMarine drugs
dc.source.countrySwitzerland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International