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dc.contributor.authorHuo, Liujie
dc.contributor.authorHug, Joachim J
dc.contributor.authorFu, Chengzhang
dc.contributor.authorBian, Xiaoying
dc.contributor.authorZhang, Youming
dc.contributor.authorMüller, Rolf
dc.date.accessioned2021-08-19T14:53:18Z
dc.date.available2021-08-19T14:53:18Z
dc.date.issued2019-01-08
dc.identifier.citationNat Prod Rep. 2019 Oct 16;36(10):1412-1436. doi: 10.1039/c8np00091c.en_US
dc.identifier.pmid30620035
dc.identifier.doi10.1039/c8np00091c
dc.identifier.urihttp://hdl.handle.net/10033/622991
dc.description.abstractCovering: 2013 to June 2018 Heterologous expression of natural product biosynthetic pathways is of increasing interest in microbial biotechnology, drug discovery and optimization. It empowers not only the robust production of valuable biomolecules in more amenable heterologous hosts but also permits the generation of novel analogs through biosynthetic engineering. This strategy also facilitates the discovery of novel bioactive compounds following the functional expression of cryptic biosynthetic gene clusters (BGCs) from fastidious original producers or metagenomic DNA in surrogate hosts, thus facilitating genome mining in the post-genomic era. This review discusses recent advances and trends pertaining to the heterologous production of bacterial natural products, with an emphasis on new techniques, heterologous hosts, and novel chemistry since 2013.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleHeterologous expression of bacterial natural product biosynthetic pathways.en_US
dc.typeReviewen_US
dc.identifier.eissn1460-4752
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalNatural product reportsen_US
dc.source.volume36
dc.source.issue10
dc.source.beginpage1412
dc.source.endpage1436
refterms.dateFOA2021-08-19T14:53:18Z
dc.source.journaltitleNatural product reports
dc.source.countryEngland


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