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dc.contributor.authorReinecke, Birthe
dc.contributor.authorKlöhn, Mara
dc.contributor.authorBrüggemann, Yannick
dc.contributor.authorKinast, Volker
dc.contributor.authorTodt, Daniel
dc.contributor.authorStang, Alexander
dc.contributor.authorBadenhorst, Marcha
dc.contributor.authorKoeppel, Katja
dc.contributor.authorGuthrie, Alan
dc.contributor.authorGroner, Ursula
dc.contributor.authorPuff, Christina
dc.contributor.authorde le Roi, Madeleine
dc.contributor.authorBaumgärtner, Wolfgang
dc.contributor.authorCavalleri, Jessika-M V
dc.contributor.authorSteinmann, Eike
dc.date.accessioned2021-08-30T10:11:16Z
dc.date.available2021-08-30T10:11:16Z
dc.date.issued2021-07-26
dc.identifier.citationViruses. 2021 Jul 26;13(8):1454. doi: 10.3390/v13081454.en_US
dc.identifier.pmid34452320
dc.identifier.doi10.3390/v13081454
dc.identifier.urihttp://hdl.handle.net/10033/623004
dc.description.abstractThe intriguing structural complexity of molecules produced by natural organisms is uncontested. Natural scaffolds serve as an important basis for the development of molecules with broad applications, e.g., therapeutics or agrochemicals. Research in recent decades has demonstrated that by means of classic metabolite extraction from microbes only a small portion of natural products can be accessed. The use of genome mining and heterologous expression approaches represents a promising way to discover new natural compounds. In this paper we report the discovery of a novel cyclic pentapeptide called bonsecamin through the heterologous expression of a cryptic NRPS gene cluster from Streptomyces albus ssp. chlorinus NRRL B-24108 in Streptomyces albus Del14. The new compound was successfully isolated and structurally characterized using NMR. The minimal set of genes required for bonsecamin production was determined through bioinformatic analysis and gene deletion experiments. A biosynthetic route leading to the production of bonsecamin is proposed in this paper.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectTheiler’s diseaseen_US
dc.subjectequine parvovirus hepatitisen_US
dc.subjecthepatopathyen_US
dc.subjectpersistent viremiaen_US
dc.subjectphylogenyen_US
dc.titleClinical Course of Infection and Cross-Species Detection of Equine Parvovirus-Hepatitis.en_US
dc.typeArticleen_US
dc.identifier.eissn1999-4915
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalVirusesen_US
dc.source.volume13
dc.source.issue8
dc.source.journaltitleViruses
dc.source.countrySwitzerland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International