Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life.
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Authors
Jacobsen, HenningWalendy-Gnirß, Kerstin
Tekin-Bubenheim, Nilgün
Kouassi, Nancy Mounogou
Ben-Batalla, Isabel
Berenbrok, Nikolaus
Wolff, Martin
Dos Reis, Vinicius Pinho
Zickler, Martin
Scholl, Lucas
Gries, Annette
Jania, Hanna
Kloetgen, Andreas
Düsedau, Arne
Pilnitz-Stolze, Gundula
Jeridi, Aicha
Yildirim, Ali Önder
Fuchs, Helmut
Gailus-Durner, Valerie
Stoeger, Claudia
de Angelis, Martin Hrabe
Manuylova, Tatjana
Klingel, Karin
Culley, Fiona J
Behrends, Jochen
Loges, Sonja
Schneider, Bianca
Krauss-Etschmann, Susanne
Openshaw, Peter
Gabriel, Gülsah
Issue Date
2021-08-16
Metadata
Show full item recordAbstract
Influenza during pregnancy can affect the health of offspring in later life, among which neurocognitive disorders are among the best described. Here, we investigate whether maternal influenza infection has adverse effects on immune responses in offspring. We establish a two-hit mouse model to study the effect of maternal influenza A virus infection (first hit) on vulnerability of offspring to heterologous infections (second hit) in later life. Offspring born to influenza A virus infected mothers are stunted in growth and more vulnerable to heterologous infections (influenza B virus and MRSA) than those born to PBS- or poly(I:C)-treated mothers. Enhanced vulnerability to infection in neonates is associated with reduced haematopoetic development and immune responses. In particular, alveolar macrophages of offspring exposed to maternal influenza have reduced capacity to clear second hit pathogens. This impaired pathogen clearance is partially reversed by adoptive transfer of alveolar macrophages from healthy offspring born to uninfected dams. These findings suggest that maternal influenza infection may impair immune ontogeny and increase susceptibility to early life infections of offspring.Citation
Nat Commun. 2021 Aug 16;12(1):4957. doi: 10.1038/s41467-021-25220-3.Affiliation
BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.Publisher
Springer NatureJournal
Nature communicationsPubMed ID
34400653Type
ArticleLanguage
enEISSN
2041-1723ae974a485f413a2113503eed53cd6c53
10.1038/s41467-021-25220-3
Scopus Count
The following license files are associated with this item:
- Creative Commons
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