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dc.contributor.authorWang, Bryan
dc.contributor.authorLin, Yu-Cheng
dc.contributor.authorVasquez-Rifo, Alejandro
dc.contributor.authorJo, Jeanyoung
dc.contributor.authorPrice-Whelan, Alexa
dc.contributor.authorMcDonald, Shujuan Tao
dc.contributor.authorBrown, Lewis M
dc.contributor.authorSieben, Christian
dc.contributor.authorDietrich, Lars E P
dc.date.accessioned2021-09-06T12:19:38Z
dc.date.available2021-09-06T12:19:38Z
dc.date.issued2021-07-29
dc.identifier.citationNat Commun. 2021 Jul 29;12(1):4613. doi: 10.1038/s41467-021-24796-0.en_US
dc.identifier.pmid34326342
dc.identifier.doi10.1038/s41467-021-24796-0
dc.identifier.urihttp://hdl.handle.net/10033/623014
dc.description.abstractR-bodies are long, extendable protein polymers formed in the cytoplasm of some bacteria; they are best known for their role in killing of paramecia by bacterial endosymbionts. Pseudomonas aeruginosa PA14, an opportunistic pathogen of diverse hosts, contains genes (referred to as the reb cluster) with potential to confer production of R-bodies and that have been implicated in virulence. Here, we show that products of the PA14 reb cluster associate with R-bodies and control stochastic expression of R-body structural genes. PA14 expresses reb genes during colonization of plant and nematode hosts, and R-body production is required for full virulence in nematodes. Analyses of nematode ribosome content and immune response indicate that P. aeruginosa R-bodies act via a mechanism involving ribosome cleavage and translational inhibition. Our observations provide insight into the biology of R-body production and its consequences during P. aeruginosa infection.en_US
dc.language.isoenen_US
dc.publisherNatureen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titlePseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence.en_US
dc.typeArticleen_US
dc.identifier.eissn2041-1723
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalNature communicationsen_US
dc.source.volume12
dc.source.issue1
dc.source.beginpage4613
dc.source.endpage
refterms.dateFOA2021-09-06T12:19:39Z
dc.source.journaltitleNature communications
dc.source.countryUnited States
dc.source.countryEngland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International