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dc.contributor.authorMourits, Vera P
dc.contributor.authorHelder, Leonie S
dc.contributor.authorMatzaraki, Vasiliki
dc.contributor.authorKoeken, Valerie A C M
dc.contributor.authorGroh, Laszlo
dc.contributor.authorde Bree, L Charlotte J
dc.contributor.authorMoorlag, Simone J C F M
dc.contributor.authorvan der Heijden, Charlotte D C C
dc.contributor.authorKeating, Samuel T
dc.contributor.authorvan Puffelen, Jelmer H
dc.contributor.authorJaeger, Martin
dc.contributor.authorJoosten, Leo A B
dc.contributor.authorNetea, Mihai G
dc.date.accessioned2021-09-13T11:16:45Z
dc.date.available2021-09-13T11:16:45Z
dc.date.issued2021-06-12
dc.identifier.citationCell Immunol. 2021 Aug;366:104393. doi: 10.1016/j.cellimm.2021.104393. Epub 2021 Jun 12.en_US
dc.identifier.pmid34147841
dc.identifier.doi10.1016/j.cellimm.2021.104393
dc.identifier.urihttp://hdl.handle.net/10033/623024
dc.description.abstractSirtuin 1 (SIRT1) has been described to modify immune responses by modulation of gene transcription. As transcriptional reprogramming is the molecular substrate of trained immunity, a de facto innate immune memory, we investigated the role of SIRT1 in the induction of trained immunity. We identified various SIRT1 genetic single nucleotide polymorphisms affecting innate and adaptive cytokine production of human peripheral blood mononuclear cells (PBMCs) in response to various stimuli on the one hand, and in vitro induction of trained immunity on the other hand. Furthermore, inhibition of SIRT1 upregulated pro-inflammatory innate cytokine production upon stimulation of PBMCs. However, inhibition of SIRT1 in vitro had no effect on cytokine responses upon induction of trained immunity, while activation of SIRT1 mildly modified trained immunity responses. In conclusion, SIRT1 modifies innate cytokine production by PBMCs in response to various microbes, but has only a secondary role for BCG and β-glucan-induced trained immunity responses.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectInflammationen_US
dc.subjectSirtuin 1en_US
dc.subjectTrained immunityen_US
dc.titleThe role of sirtuin 1 on the induction of trained immunity.en_US
dc.typeArticleen_US
dc.identifier.eissn1090-2163
dc.contributor.departmentCiiM, Zentrum für individualisierte Infektionsmedizin, Feodor-Lynen-Str.7, 30625 Hannover.en_US
dc.identifier.journalCellular immunologyen_US
dc.source.volume366
dc.source.beginpage104393
dc.source.endpage
refterms.dateFOA2021-09-13T11:16:45Z
dc.source.journaltitleCellular immunology
dc.source.countryNetherlands


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International