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dc.contributor.authorBöhme, Katja
dc.contributor.authorHeroven, Ann Kathrin
dc.contributor.authorLobedann, Stephanie
dc.contributor.authorGuo, Yuzhu
dc.contributor.authorStolle, Anne-Sophie
dc.contributor.authorDersch, Petra
dc.date.accessioned2021-09-13T14:00:13Z
dc.date.available2021-09-13T14:00:13Z
dc.date.issued2021-08-03
dc.identifier.citationFront Microbiol. 2021 Aug 3;12:706934. doi: 10.3389/fmicb.2021.706934.en_US
dc.identifier.issn1664-302X
dc.identifier.pmid34413840
dc.identifier.doi10.3389/fmicb.2021.706934
dc.identifier.urihttp://hdl.handle.net/10033/623027
dc.description.abstractVirulence gene expression of Yersinia pseudotuberculosis changes during the different stages of infection and this is tightly controlled by environmental cues. In this study, we show that the small protein YmoA, a member of the Hha family, is part of this process. It controls temperature- and nutrient-dependent early and later stage virulence genes in an opposing manner and co-regulates bacterial stress responses and metabolic functions. Our analysis further revealed that YmoA exerts this function by modulating the global post-transcriptional regulatory Csr system. YmoA pre-dominantly enhances the stability of the regulatory RNA CsrC. This involves a stabilizing stem-loop structure within the 5'-region of CsrC. YmoA-mediated CsrC stabilization depends on H-NS, but not on the RNA chaperone Hfq. YmoA-promoted reprogramming of the Csr system has severe consequences for the cell: we found that a mutant deficient of ymoA is strongly reduced in its ability to enter host cells and to disseminate to the Peyer's patches, mesenteric lymph nodes, liver and spleen in mice. We propose a model in which YmoA controls transition from the initial colonization phase in the intestine toward the host defense phase important for the long-term establishment of the infection in underlying tissues.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCsrAen_US
dc.subjectHhaen_US
dc.subjectYersiniaen_US
dc.subjectYmoAen_US
dc.subjectgene regulationen_US
dc.subjectregulatory RNAen_US
dc.subjectvirulenceen_US
dc.titleThe Small Protein YmoA Controls the Csr System and Adjusts Expression of Virulence-Relevant Traits of .en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalFrontiers in microbiologyen_US
dc.source.volume12
dc.source.beginpage706934
dc.source.endpage
refterms.dateFOA2021-09-13T14:00:14Z
dc.source.journaltitleFrontiers in microbiology
dc.source.countrySwitzerland


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Except where otherwise noted, this item's license is described as Attribution 4.0 International