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dc.contributor.authorKhodamoradi, Shadi
dc.contributor.authorHahnke, Richard L
dc.contributor.authorMast, Yvonne
dc.contributor.authorSchumann, Peter
dc.contributor.authorKämpfer, Peter
dc.contributor.authorSteinert, Michael
dc.contributor.authorRückert, Christian
dc.contributor.authorSurup, Frank
dc.contributor.authorRohde, Manfred
dc.contributor.authorWink, Joachim
dc.date.accessioned2021-09-20T09:55:10Z
dc.date.available2021-09-20T09:55:10Z
dc.date.issued2021-08-06
dc.identifier.citationAntonie Van Leeuwenhoek. 2021 Oct;114(10):1483-1496. doi: 10.1007/s10482-021-01609-4. Epub 2021 Aug 6.en_US
dc.identifier.pmid34355285
dc.identifier.doi10.1007/s10482-021-01609-4
dc.identifier.urihttp://hdl.handle.net/10033/623039
dc.description.abstractStrain M2T was isolated from the beach of Cuxhaven, Wadden Sea, Germany, in course of a program to attain new producers of bioactive natural products. Strain M2T produces litoralimycin and sulfomycin-type thiopeptides. Bioinformatic analysis revealed a potential biosynthetic gene cluster encoding for the M2T thiopeptides. The strain is Gram-stain-positive, rod shaped, non-motile, spore forming, showing a yellow colony color and forms extensively branched substrate mycelium and aerial hyphae. Inferred from the 16S rRNA gene phylogeny strain M2T affiliates with the genus Streptomonospora. It shows 96.6% 16S rRNA gene sequence similarity to the type species Streptomonospora salina DSM 44593 T and forms a distinct branch with Streptomonospora sediminis DSM 45723 T with 97.0% 16S rRNA gene sequence similarity. Genome-based phylogenetic analysis revealed that M2T is closely related to Streptomonospora alba YIM 90003 T with a digital DNA-DNA hybridisation (dDDH) value of 26.6%. The predominant menaquinones of M2T are MK-10(H6), MK-10(H8), and MK-11(H6) (> 10%). Major cellular fatty acids are iso-C16:0, anteiso C17:0 and C18:0 10-methyl. The polar lipid profile consisted of diphosphatidylglycerol phosphatidyl glycerol, phosphatidylinositol, phosphatidylcholine, phosphatidylethanolamine, three glycolipids, two unknown phospholipids, and two unknown lipids. The genome size of type strain M2T is 5,878,427 bp with 72.1 mol % G + C content. Based on the results obtained from phylogenetic and chemotaxonomic studies, strain M2T (= DSM 106425 T = NCCB 100650 T) is considered to represent a novel species within the genus Streptomonospora for which the name Streptomonospora litoralis sp. nov. is proposed.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectActinobacteriaen_US
dc.subjectPolyphasic taxonomyen_US
dc.subjectRare actinomyceteen_US
dc.subjectStreptomonospora litoralis sp.en_US
dc.subjectThiopeptideen_US
dc.titleStreptomonospora litoralis sp. nov., a halophilic thiopeptides producer isolated from sand collected at Cuxhaven beach.en_US
dc.typeArticleen_US
dc.identifier.eissn1572-9699
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalAntonie van Leeuwenhoeken_US
dc.source.volume114
dc.source.issue10
dc.source.beginpage1483
dc.source.endpage1496
refterms.dateFOA2021-09-20T09:55:11Z
dc.source.journaltitleAntonie van Leeuwenhoek
dc.source.countryNetherlands


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