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dc.contributor.authorMeyer-Hermann, Michael
dc.date.accessioned2021-09-21T09:04:49Z
dc.date.available2021-09-21T09:04:49Z
dc.date.issued2021-08-24
dc.identifier.citationCell Rep. 2021 Aug 24;36(8):109552. doi: 10.1016/j.celrep.2021.109552. PMID: 34433043.en_US
dc.identifier.pmid34433043
dc.identifier.doi10.1016/j.celrep.2021.109552
dc.identifier.urihttp://hdl.handle.net/10033/623040
dc.description.abstractThe selection of B cells (BCs) in germinal centers (GCs) is pivotal to the generation of high-affinity antibodies and memory BCs, but it lacks global understanding. Based on the idea of a single Tfh-cell signal that controls BC selection and division, experiments appear contradictory. Here, we use the current knowledge on the molecular pathways of GC BCs to develop a theory of GC BC selection and division based on the dynamics of molecular factors. This theory explains the seemingly contradictory experiments by the separation of signals for BC fate decision from signals controlling the number of BC divisions. Three model variants are proposed and experiments are predicted that allow one to distinguish those. Understanding information processing in molecular BC states is critical for targeted immune interventions, and the proposed theory implies that selection and division can be controlled independently in GC reactions.en_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectB cell divisionen_US
dc.subjectB cell selectionen_US
dc.subjectB cell signalingen_US
dc.subjectFoxO1en_US
dc.subjectaffinity maturationen_US
dc.subjectc-Mycen_US
dc.subjectcomputer simulationen_US
dc.subjectgerminal centeren_US
dc.subjectmTORen_US
dc.subjectmathematical modelen_US
dc.titleA molecular theory of germinal center B cell selection and division.en_US
dc.typeArticleen_US
dc.identifier.eissn2211-1247
dc.contributor.departmentBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.en_US
dc.identifier.journalCell reportsen_US
dc.source.volume36
dc.source.issue8
dc.source.beginpage109552
dc.source.endpage
refterms.dateFOA2021-09-21T09:04:49Z
dc.source.journaltitleCell reports
dc.source.countryUnited States


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International