Show simple item record

dc.contributor.authorKilic, Gizem
dc.contributor.authorBulut, Ozlem
dc.contributor.authorJaeger, Martin
dc.contributor.authorTer Horst, Rob
dc.contributor.authorKoeken, Valerie A C M
dc.contributor.authorMoorlag, Simone J C F M
dc.contributor.authorMourits, Vera P
dc.contributor.authorde Bree, Charlotte
dc.contributor.authorDomínguez-Andrés, Jorge
dc.contributor.authorJoosten, Leo A B
dc.contributor.authorNetea, Mihai G
dc.date.accessioned2021-09-27T09:37:43Z
dc.date.available2021-09-27T09:37:43Z
dc.date.issued2021-08-09
dc.identifier.citationFront Immunol. 2021 Aug 9;12:720090. doi: 10.3389/fimmu.2021.720090.en_US
dc.identifier.pmid34434199
dc.identifier.doi10.3389/fimmu.2021.720090
dc.identifier.urihttp://hdl.handle.net/10033/623044
dc.description.abstractMale sex and old age are risk factors for COVID-19 severity, but the underlying causes are unknown. A possible explanation for this might be the differences in immunological profiles in males and the elderly before the infection. With this in mind, we analyzed the abundance of circulating proteins and immune populations associated with severe COVID-19 in 2 healthy cohorts. Besides, given the seasonal profile of COVID-19, the seasonal response against SARS-CoV-2 could also be different in the elderly and males. Therefore, PBMCs of female, male, young, and old subjects in different seasons of the year were stimulated with heat-inactivated SARS-CoV-2 to investigate the season-dependent anti-SARS-CoV-2 immune response. We found that several T cell subsets, which are known to be depleted in severe COVID-19 patients, were intrinsically less abundant in men and older individuals. Plasma proteins increasing with disease severity, including HGF, IL-8, and MCP-1, were more abundant in the elderly and males. Upon in vitro SARS-CoV-2 stimulation, the elderly produced significantly more IL-1RA and had a dysregulated IFNγ response with lower production in the fall compared with young individuals. Our results suggest that the immune characteristics of severe COVID-19, described by a differential abundance of immune cells and circulating inflammatory proteins, are intrinsically present in healthy men and the elderly. This might explain the susceptibility of men and the elderly to SARS-CoV-2 infection.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectagingen_US
dc.subjectinfectionen_US
dc.subjectseasonalityen_US
dc.subjectsex differencesen_US
dc.titleThe Immunological Factors Predisposing to Severe Covid-19 Are Already Present in Healthy Elderly and Men.en_US
dc.typeArticleen_US
dc.identifier.eissn1664-3224
dc.contributor.departmentCiiM, Zentrum für individualisierte Infektionsmedizin, Feodor-Lynen-Str.7, 30625 Hannover.en_US
dc.identifier.journalFrontiers in immunologyen_US
dc.source.volume12
dc.source.beginpage720090
dc.source.endpage
refterms.dateFOA2021-09-27T09:37:44Z
dc.source.journaltitleFrontiers in immunology
dc.source.countrySwitzerland


Files in this item

Thumbnail
Name:
Kilic et al.pdf
Size:
6.838Mb
Format:
PDF
Description:
Open Access publication

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International