Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Böttcher, Jan P
Pachmayr, Ludwig O
Chaudhry, M Zeeshan
Busch, Dirk H
Sun, Joseph C
Victora, Gabriel D
Buchholz, Veit R
MetadataShow full item record
AbstractUpon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors are selected, expanded, and maintained in an adaptive-like manner. Currently, these are thought to differentiate along a common pathway. However, by fate mapping of single NK cells upon murine cytomegalovirus (MCMV) infection, we identified two distinct NK cell lineages that contributed to adaptive-like responses. One was equivalent to conventional NK (cNK) cells while the other was transcriptionally similar to type 1 innate lymphoid cells (ILC1s). ILC1-like NK cells showed splenic residency and strong cytokine production but also recognized and killed MCMV-infected cells, guided by activating receptor Ly49H. Moreover, they induced clustering of conventional type 1 dendritic cells and facilitated antigen-specific T cell priming early during MCMV infection, which depended on Ly49H and the NK cell-intrinsic expression of transcription factor Batf3. Thereby, ILC1-like NK cells bridge innate and adaptive viral recognition and unite critical features of cNK cells and ILC1s.
CitationImmunity. 2021 Aug 20:S1074-7613(21)00332-0. doi: 10.1016/j.immuni.2021.08.002. Epub ahead of print.
AffiliationHZI, Helmholtz Zentrum für Infektionsforschung, GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
The following license files are associated with this item:
- Creative Commons
- Cmv1-independent antiviral role of NK cells revealed in murine cytomegalovirus-infected New Zealand White mice.
- Authors: Rodriguez M, Sabastian P, Clark P, Brown MG
- Issue date: 2004 Nov 15
- Cytokine-Mediated Activation of NK Cells during Viral Infection.
- Authors: Freeman BE, Raué HP, Hill AB, Slifka MK
- Issue date: 2015 Aug
- Natural Killer Cell Sensing of Infected Cells Compensates for MyD88 Deficiency but Not IFN-I Activity in Resistance to Mouse Cytomegalovirus.
- Authors: Cocita C, Guiton R, Bessou G, Chasson L, Boyron M, Crozat K, Dalod M
- Issue date: 2015 May
- Ly49h-deficient C57BL/6 mice: a new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complex.
- Authors: Fodil-Cornu N, Lee SH, Belanger S, Makrigiannis AP, Biron CA, Buller RM, Vidal SM
- Issue date: 2008 Nov 1
- Cytomegalovirus Evades TRAIL-Mediated Innate Lymphoid Cell 1 Defenses.
- Authors: Picarda G, Ghosh R, McDonald B, Verma S, Thiault N, El Morabiti R, Griffith TS, Benedict CA
- Issue date: 2019 Aug 15