Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection.
dc.contributor.author | Flommersfeld, Sophie | |
dc.contributor.author | Böttcher, Jan P | |
dc.contributor.author | Ersching, Jonatan | |
dc.contributor.author | Flossdorf, Michael | |
dc.contributor.author | Meiser, Philippa | |
dc.contributor.author | Pachmayr, Ludwig O | |
dc.contributor.author | Leube, Justin | |
dc.contributor.author | Hensel, Inge | |
dc.contributor.author | Jarosch, Sebastian | |
dc.contributor.author | Zhang, Qin | |
dc.contributor.author | Chaudhry, M Zeeshan | |
dc.contributor.author | Andrae, Immanuel | |
dc.contributor.author | Schiemann, Matthias | |
dc.contributor.author | Busch, Dirk H | |
dc.contributor.author | Cicin-Sain, Luka | |
dc.contributor.author | Sun, Joseph C | |
dc.contributor.author | Gasteiger, Georg | |
dc.contributor.author | Victora, Gabriel D | |
dc.contributor.author | Höfer, Thomas | |
dc.contributor.author | Buchholz, Veit R | |
dc.contributor.author | Grassmann, Simon | |
dc.date.accessioned | 2021-10-04T20:23:16Z | |
dc.date.available | 2021-10-04T20:23:16Z | |
dc.date.issued | 2021-08-20 | |
dc.identifier.citation | Immunity. 2021 Aug 20:S1074-7613(21)00332-0. doi: 10.1016/j.immuni.2021.08.002. Epub ahead of print. | en_US |
dc.identifier.pmid | 34437840 | |
dc.identifier.doi | 10.1016/j.immuni.2021.08.002 | |
dc.identifier.uri | http://hdl.handle.net/10033/623061 | |
dc.description.abstract | Upon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors are selected, expanded, and maintained in an adaptive-like manner. Currently, these are thought to differentiate along a common pathway. However, by fate mapping of single NK cells upon murine cytomegalovirus (MCMV) infection, we identified two distinct NK cell lineages that contributed to adaptive-like responses. One was equivalent to conventional NK (cNK) cells while the other was transcriptionally similar to type 1 innate lymphoid cells (ILC1s). ILC1-like NK cells showed splenic residency and strong cytokine production but also recognized and killed MCMV-infected cells, guided by activating receptor Ly49H. Moreover, they induced clustering of conventional type 1 dendritic cells and facilitated antigen-specific T cell priming early during MCMV infection, which depended on Ly49H and the NK cell-intrinsic expression of transcription factor Batf3. Thereby, ILC1-like NK cells bridge innate and adaptive viral recognition and unite critical features of cNK cells and ILC1s. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Cell Press | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | ILC1 | en_US |
dc.subject | ILC1-like NK cells | en_US |
dc.subject | MCMV | en_US |
dc.subject | NK cells | en_US |
dc.subject | adaptive-like NK cell responses | en_US |
dc.subject | single-cell fate mapping | en_US |
dc.title | Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection. | en_US |
dc.type | Article | en_US |
dc.identifier.eissn | 1097-4180 | |
dc.contributor.department | HZI, Helmholtz Zentrum für Infektionsforschung, GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany. | en_US |
dc.identifier.journal | Immunity | en_US |
dc.description.admin-note | OpenAccess-article (HybridOA) | en |
refterms.dateFOA | 2021-10-04T20:23:16Z | |
atmire.accessrights | OpenAccess-article (HybridOA) | en |
dc.source.journaltitle | Immunity | |
dc.source.country | United States |