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dc.contributor.authorFlommersfeld, Sophie
dc.contributor.authorBöttcher, Jan P
dc.contributor.authorErsching, Jonatan
dc.contributor.authorFlossdorf, Michael
dc.contributor.authorMeiser, Philippa
dc.contributor.authorPachmayr, Ludwig O
dc.contributor.authorLeube, Justin
dc.contributor.authorHensel, Inge
dc.contributor.authorJarosch, Sebastian
dc.contributor.authorZhang, Qin
dc.contributor.authorChaudhry, M Zeeshan
dc.contributor.authorAndrae, Immanuel
dc.contributor.authorSchiemann, Matthias
dc.contributor.authorBusch, Dirk H
dc.contributor.authorCicin-Sain, Luka
dc.contributor.authorSun, Joseph C
dc.contributor.authorGasteiger, Georg
dc.contributor.authorVictora, Gabriel D
dc.contributor.authorHöfer, Thomas
dc.contributor.authorBuchholz, Veit R
dc.contributor.authorGrassmann, Simon
dc.date.accessioned2021-10-04T20:23:16Z
dc.date.available2021-10-04T20:23:16Z
dc.date.issued2021-08-20
dc.identifier.citationImmunity. 2021 Aug 20:S1074-7613(21)00332-0. doi: 10.1016/j.immuni.2021.08.002. Epub ahead of print.en_US
dc.identifier.pmid34437840
dc.identifier.doi10.1016/j.immuni.2021.08.002
dc.identifier.urihttp://hdl.handle.net/10033/623061
dc.description.abstractUpon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors are selected, expanded, and maintained in an adaptive-like manner. Currently, these are thought to differentiate along a common pathway. However, by fate mapping of single NK cells upon murine cytomegalovirus (MCMV) infection, we identified two distinct NK cell lineages that contributed to adaptive-like responses. One was equivalent to conventional NK (cNK) cells while the other was transcriptionally similar to type 1 innate lymphoid cells (ILC1s). ILC1-like NK cells showed splenic residency and strong cytokine production but also recognized and killed MCMV-infected cells, guided by activating receptor Ly49H. Moreover, they induced clustering of conventional type 1 dendritic cells and facilitated antigen-specific T cell priming early during MCMV infection, which depended on Ly49H and the NK cell-intrinsic expression of transcription factor Batf3. Thereby, ILC1-like NK cells bridge innate and adaptive viral recognition and unite critical features of cNK cells and ILC1s.en_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectILC1en_US
dc.subjectILC1-like NK cellsen_US
dc.subjectMCMVen_US
dc.subjectNK cellsen_US
dc.subjectadaptive-like NK cell responsesen_US
dc.subjectsingle-cell fate mappingen_US
dc.titleFate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection.en_US
dc.typeArticleen_US
dc.identifier.eissn1097-4180
dc.contributor.departmentHZI, Helmholtz Zentrum für Infektionsforschung, GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en_US
dc.identifier.journalImmunityen_US
dc.description.admin-noteOpenAccess-article (HybridOA)en
refterms.dateFOA2021-10-04T20:23:16Z
atmire.accessrightsOpenAccess-article (HybridOA)en
dc.source.journaltitleImmunity
dc.source.countryUnited States


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International