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dc.contributor.authorGaur, Pratibha
dc.contributor.authorRiehn, Mathias
dc.contributor.authorZha, Lisha
dc.contributor.authorKöster, Mario
dc.contributor.authorHauser, Hansjörg
dc.contributor.authorWirth, Dagmar
dc.date.accessioned2021-10-08T09:22:11Z
dc.date.available2021-10-08T09:22:11Z
dc.date.issued2021-07-27
dc.identifier.citationObesity (Silver Spring). 2021 Aug;29(8):1272-1278. doi: 10.1002/oby.23196.en_US
dc.identifier.pmid34314110
dc.identifier.doi10.1002/oby.23196
dc.identifier.urihttp://hdl.handle.net/10033/623067
dc.description.abstractObjective: Obesity is a major risk factor that increases morbidity and mortality upon infection. Although type I and type III interferon (IFN)-induced innate immune responses represent the first line of defense against viral infections, their functionality in the context of metabolic disorders remains largely obscure. This study aimed to investigate IFN responses upon respiratory viral infection in obese mice. Methods: The activation of IFNs as well as IFN regulatory factors (IRFs) upon H3N2 influenza infection in mice upon high-fat-diet feeding was investigated. Results: Influenza infection of obese mice was characterized by higher mortalities. In-depth analysis revealed impaired induction of both type I and type III IFNs as well as markedly reduced IFN responses. Notably, it was found that IRF7 gene expression in obese animals was reduced in homeostasis, and its induction by the virus was strongly attenuated. Conclusions: The results suggest that the attenuated IRF7 expression and induction are responsible for the reduced expression levels of type I and III IFNs and, thus, for the higher susceptibility and severity of respiratory infections in obese mice. © 2021 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleDefective interferon amplification and impaired host responses against influenza virus in obese mice.en_US
dc.typeArticleen_US
dc.identifier.eissn1930-739X
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalObesity (Silver Spring, Md.)en_US
dc.source.volume29
dc.source.issue8
dc.source.beginpage1272
dc.source.endpage1278
refterms.dateFOA2021-10-08T09:22:12Z
dc.source.journaltitleObesity (Silver Spring, Md.)
dc.source.countryUnited States


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Attribution-NonCommercial-NoDerivatives 4.0 International
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