Towards the sustainable discovery and development of new antibiotics.
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Authors
Miethke, MarcusPieroni, Marco
Weber, Tilmann
Brönstrup, Mark

Hammann, Peter
Halby, Ludovic
Arimondo, Paola B
Glaser, Philippe
Aigle, Bertrand
Bode, Helge B
Moreira, Rui
Li, Yanyan
Luzhetskyy, Andriy
Medema, Marnix H
Pernodet, Jean-Luc
Stadler, Marc
Tormo, José Rubén
Genilloud, Olga
Truman, Andrew W
Weissman, Kira J
Takano, Eriko
Sabatini, Stefano
Stegmann, Evi
Brötz-Oesterhelt, Heike
Wohlleben, Wolfgang
Seemann, Myriam
Empting, Martin
Hirsch, Anna K H
Loretz, Brigitta
Lehr, Claus-Michael
Titz, Alexander
Herrmann, Jennifer

Jaeger, Timo
Alt, Silke
Hesterkamp, Thomas
Winterhalter, Mathias
Schiefer, Andrea
Pfarr, Kenneth
Hoerauf, Achim
Graz, Heather
Graz, Michael
Lindvall, Mika
Ramurthy, Savithri
Karlén, Anders
van Dongen, Maarten
Petkovic, Hrvoje
Keller, Andreas
Peyrane, Frédéric
Donadio, Stefano
Fraisse, Laurent
Piddock, Laura J V
Gilbert, Ian H
Moser, Heinz E
Müller, Rolf
Issue Date
2021-08-19
Metadata
Show full item recordAbstract
An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations.Citation
Nat Rev Chem. 2021 Aug 19:1-24. doi: 10.1038/s41570-021-00313-1. Epub ahead of print.Affiliation
HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.Publisher
Springer NatureJournal
Nature reviews. ChemistryPubMed ID
34426795Type
ReviewLanguage
enISSN
2397-3358ae974a485f413a2113503eed53cd6c53
10.1038/s41570-021-00313-1
Scopus Count
The following license files are associated with this item:
- Creative Commons
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