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dc.contributor.authorMiethke, Marcus
dc.contributor.authorPieroni, Marco
dc.contributor.authorWeber, Tilmann
dc.contributor.authorBrönstrup, Mark
dc.contributor.authorHammann, Peter
dc.contributor.authorHalby, Ludovic
dc.contributor.authorArimondo, Paola B
dc.contributor.authorGlaser, Philippe
dc.contributor.authorAigle, Bertrand
dc.contributor.authorBode, Helge B
dc.contributor.authorMoreira, Rui
dc.contributor.authorLi, Yanyan
dc.contributor.authorLuzhetskyy, Andriy
dc.contributor.authorMedema, Marnix H
dc.contributor.authorPernodet, Jean-Luc
dc.contributor.authorStadler, Marc
dc.contributor.authorTormo, José Rubén
dc.contributor.authorGenilloud, Olga
dc.contributor.authorTruman, Andrew W
dc.contributor.authorWeissman, Kira J
dc.contributor.authorTakano, Eriko
dc.contributor.authorSabatini, Stefano
dc.contributor.authorStegmann, Evi
dc.contributor.authorBrötz-Oesterhelt, Heike
dc.contributor.authorWohlleben, Wolfgang
dc.contributor.authorSeemann, Myriam
dc.contributor.authorEmpting, Martin
dc.contributor.authorHirsch, Anna K H
dc.contributor.authorLoretz, Brigitta
dc.contributor.authorLehr, Claus-Michael
dc.contributor.authorTitz, Alexander
dc.contributor.authorHerrmann, Jennifer
dc.contributor.authorJaeger, Timo
dc.contributor.authorAlt, Silke
dc.contributor.authorHesterkamp, Thomas
dc.contributor.authorWinterhalter, Mathias
dc.contributor.authorSchiefer, Andrea
dc.contributor.authorPfarr, Kenneth
dc.contributor.authorHoerauf, Achim
dc.contributor.authorGraz, Heather
dc.contributor.authorGraz, Michael
dc.contributor.authorLindvall, Mika
dc.contributor.authorRamurthy, Savithri
dc.contributor.authorKarlén, Anders
dc.contributor.authorvan Dongen, Maarten
dc.contributor.authorPetkovic, Hrvoje
dc.contributor.authorKeller, Andreas
dc.contributor.authorPeyrane, Frédéric
dc.contributor.authorDonadio, Stefano
dc.contributor.authorFraisse, Laurent
dc.contributor.authorPiddock, Laura J V
dc.contributor.authorGilbert, Ian H
dc.contributor.authorMoser, Heinz E
dc.contributor.authorMüller, Rolf
dc.date.accessioned2021-10-12T08:18:39Z
dc.date.available2021-10-12T08:18:39Z
dc.date.issued2021-08-19
dc.identifier.citationNat Rev Chem. 2021 Aug 19:1-24. doi: 10.1038/s41570-021-00313-1. Epub ahead of print. PMID: 34426795.en_US
dc.identifier.issn2397-3358
dc.identifier.pmid34426795
dc.identifier.doi10.1038/s41570-021-00313-1
dc.identifier.urihttp://hdl.handle.net/10033/623070
dc.description.abstractAn ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations.en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBusiness strategy in drug developmenten_US
dc.subjectDrug therapyen_US
dc.titleTowards the sustainable discovery and development of new antibiotics.en_US
dc.typeReviewen_US
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalNature reviews. Chemistryen_US
dc.source.beginpage1
dc.source.endpage24
refterms.dateFOA2021-10-12T08:18:40Z
dc.source.journaltitleNature reviews. Chemistry
dc.source.countryEngland


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