Total Synthesis of Thuggacin cmc-A and Its Structure Determination.
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Authors
Tsutsumi, TomohiroMatsumoto, Moe
Iwasaki, Hitomi
Tomisawa, Kei
Komine, Keita
Fukuda, Hayato
Eustache, Jacques
Jansen, Rolf

Hatakeyama, Susumi
Ishihara, Jun
Issue Date
2021-06-15
Metadata
Show full item recordAbstract
The first total synthesis of thuggacin cmc-A and the determination of the absolute structure are described. The thuggacin family of antibiotics is of great interest due to the antibiotic activity against Mycobacterium tuberculosis. Based on the assumption that seven stereogenic centers in thuggacin cmc-A would share the same stereochemistry as thuggacin-A, all stereogenic centers of thuggacin cmc-A were strictly constructed in a stereocontrolled manner. The total synthesis allowed its stereostructure to be fully confirmed.Citation
Org Lett. 2021 Jul 2;23(13):5208-5212. doi: 10.1021/acs.orglett.1c01743. Epub 2021 Jun 15.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
American Chemical SocietyJournal
Organic lettersPubMed ID
34128685Type
ArticleLanguage
enEISSN
1523-7052ae974a485f413a2113503eed53cd6c53
10.1021/acs.orglett.1c01743
Scopus Count
The following license files are associated with this item:
- Creative Commons