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dc.contributor.authorTsutsumi, Tomohiro
dc.contributor.authorMatsumoto, Moe
dc.contributor.authorIwasaki, Hitomi
dc.contributor.authorTomisawa, Kei
dc.contributor.authorKomine, Keita
dc.contributor.authorFukuda, Hayato
dc.contributor.authorEustache, Jacques
dc.contributor.authorJansen, Rolf
dc.contributor.authorHatakeyama, Susumi
dc.contributor.authorIshihara, Jun
dc.date.accessioned2021-10-18T13:29:37Z
dc.date.available2021-10-18T13:29:37Z
dc.date.issued2021-06-15
dc.identifier.citationOrg Lett. 2021 Jul 2;23(13):5208-5212. doi: 10.1021/acs.orglett.1c01743. Epub 2021 Jun 15.en_US
dc.identifier.pmid34128685
dc.identifier.doi10.1021/acs.orglett.1c01743
dc.identifier.urihttp://hdl.handle.net/10033/623074
dc.description.abstractThe first total synthesis of thuggacin cmc-A and the determination of the absolute structure are described. The thuggacin family of antibiotics is of great interest due to the antibiotic activity against Mycobacterium tuberculosis. Based on the assumption that seven stereogenic centers in thuggacin cmc-A would share the same stereochemistry as thuggacin-A, all stereogenic centers of thuggacin cmc-A were strictly constructed in a stereocontrolled manner. The total synthesis allowed its stereostructure to be fully confirmed.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleTotal Synthesis of Thuggacin cmc-A and Its Structure Determination.en_US
dc.typeArticleen_US
dc.identifier.eissn1523-7052
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalOrganic lettersen_US
dc.source.volume23
dc.source.issue13
dc.source.beginpage5208
dc.source.endpage5212
dc.source.journaltitleOrganic letters
dc.source.countryUnited States


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Except where otherwise noted, this item's license is described as Attribution 4.0 International