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Authors
Ye, LiqingAmbi, Uddhav B
Olguin-Nava, Marco
Gribling-Burrer, Anne-Sophie
Ahmad, Shazeb
Bohn, Patrick
Weber, Melanie M
Smyth, Redmond P
Issue Date
2021-09-08
Metadata
Show full item recordAbstract
To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs. In this review, we focus on the role of viral encoded RNA structures in genome packaging. We first discuss how packaging signals are constructed from local and long-range base pairings within viral genomes, as well as inter-molecular interactions between viral and host RNAs. Then, how genome packaging is regulated by the biophysical properties of RNA. Finally, we examine the impact of RNA packaging signals on viral evolution.Citation
Viruses. 2021 Sep 8;13(9):1788. doi: 10.3390/v13091788.Affiliation
HIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.Publisher
MDPIJournal
VirusesPubMed ID
34578369Type
ArticleLanguage
enEISSN
1999-4915ae974a485f413a2113503eed53cd6c53
10.3390/v13091788
Scopus Count
The following license files are associated with this item:
- Creative Commons
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