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dc.contributor.authorRoy, Urmi
dc.contributor.authorde Oliveira, Rômulo S
dc.contributor.authorGalvez, Eric J C
dc.contributor.authorGronow, Achim
dc.contributor.authorBasic, Marijana
dc.contributor.authorPerez, Laura Garcia
dc.contributor.authorGagliani, Nicola
dc.contributor.authorBleich, Andre
dc.contributor.authorHuber, Samuel
dc.contributor.authorStrowig, Till
dc.date.accessioned2021-11-11T13:02:14Z
dc.date.available2021-11-11T13:02:14Z
dc.date.issued2021-09-08
dc.identifier.citationFront Immunol. 2021 Sep 8;12:671331. doi: 10.3389/fimmu.2021.671331.en_US
dc.identifier.pmid34566952
dc.identifier.doi10.3389/fimmu.2021.671331
dc.identifier.urihttp://hdl.handle.net/10033/623092
dc.description.abstractThe intestinal microbiota modulates IL-22 production in the intestine, including the induction of IL-22-producing CD4+ T helper cells. Which specific bacteria are responsible for the induction of these cells is less well understood. Here, we demonstrate through the use of novel gnotobiotic knock-in reporter mice that segmented filamentous bacteria (SFB), which are known for their ability to induce Th17 cells, also induce distinct IL-17A negative CD4+ T cell populations in the intestine. A subset of these cells instead produces IL-22 upon restimulation ex vivo and also during enteric infections. Furthermore, they produce a distinct set of cytokines compared to Th17 cells including the differential expression of IL-17F and IFN-γ. Importantly, genetic models demonstrate that these cells, presumably Th22 cells, develop independently of intestinal Th17 cells. Together, our data identifies that besides Th17, SFB also induces CD4+ T cell populations, which serve as immediate source of IL-22 during intestinal inflammation.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectIL-22en_US
dc.subjectSalmonella infectionen_US
dc.subjectTh22 cellsen_US
dc.subjectbystander activation of T cellsen_US
dc.subjectcytokine knock-in reporter miceen_US
dc.subjectsegmented filamentous bacteria (SFB)en_US
dc.titleInduction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells.en_US
dc.typeArticleen_US
dc.identifier.eissn1664-3224
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalFrontiers in immunologyen_US
dc.source.volume12
dc.source.beginpage671331
dc.source.endpage
refterms.dateFOA2021-11-11T13:02:15Z
dc.source.journaltitleFrontiers in immunology
dc.source.countrySwitzerland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International