Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy.
dc.contributor.author | Bošnjak, Berislav | |
dc.contributor.author | Odak, Ivan | |
dc.contributor.author | Ritter, Christiane | |
dc.contributor.author | Stahl, Klaus | |
dc.contributor.author | Graalmann, Theresa | |
dc.contributor.author | Steinbrück, Lars | |
dc.contributor.author | Blasczyk, Rainer | |
dc.contributor.author | Falk, Christine S | |
dc.contributor.author | Schulz, Thomas F | |
dc.contributor.author | Wedemeyer, Hans Heinrich | |
dc.contributor.author | Cornberg, Markus | |
dc.contributor.author | Ganser, Arnold | |
dc.contributor.author | Förster, Reinhold | |
dc.contributor.author | Koenecke, Christian | |
dc.date.accessioned | 2021-11-15T15:11:21Z | |
dc.date.available | 2021-11-15T15:11:21Z | |
dc.date.issued | 2021-08-12 | |
dc.identifier.citation | Front Immunol. 2021 Aug 12;12:721738. doi: 10.3389/fimmu.2021.721738. | en_US |
dc.identifier.pmid | 34456929 | |
dc.identifier.doi | 10.3389/fimmu.2021.721738 | |
dc.identifier.uri | http://hdl.handle.net/10033/623096 | |
dc.description.abstract | Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Frontiers | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | CD19 CAR-T cell | en_US |
dc.subject | COVID – 19 | en_US |
dc.subject | NK cell | en_US |
dc.subject | SARS – CoV – 2 | en_US |
dc.subject | T cell | en_US |
dc.subject | convalescent plasma (CP) | en_US |
dc.title | Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy. | en_US |
dc.type | Article | en_US |
dc.identifier.eissn | 1664-3224 | |
dc.contributor.department | CiiM, Zentrum für individualisierte Infektionsmedizin, Feodor-Lynen-Str.7, 30625 Hannover. | en_US |
dc.identifier.journal | Frontiers in immunology | en_US |
dc.source.volume | 12 | |
dc.source.beginpage | 721738 | |
dc.source.endpage | ||
refterms.dateFOA | 2021-11-15T15:11:22Z | |
dc.source.journaltitle | Frontiers in immunology | |
dc.source.country | Switzerland |