Show simple item record

dc.contributor.authorRichter, Robert
dc.contributor.authorLehr, Claus-Michael
dc.date.accessioned2021-11-24T09:35:44Z
dc.date.available2021-11-24T09:35:44Z
dc.date.issued2021-04-20
dc.identifier.citationAdv Drug Deliv Rev. 2021 Jun;173:492-503. doi: 10.1016/j.addr.2021.04.010. Epub 2021 Apr 20.en_US
dc.identifier.pmid33857554
dc.identifier.doi10.1016/j.addr.2021.04.010
dc.identifier.urihttp://hdl.handle.net/10033/623101
dc.description.abstractSudden outbreaks of novel infectious diseases and the persistent evolution of antimicrobial resistant pathogens make it necessary to develop specific tools to quickly understand pathogen-cell interactions and to study appropriate drug delivery strategies. Extracellular vesicles (EVs) are cell-specific biogenic transport systems, which are gaining more and more popularity as either diagnostic markers or drug delivery systems. Apart from that, there are emerging possibilities for EVs as tools to study drug penetration, drug-membrane interactions as well as pathogen-membrane interactions. However, it appears that the potential of EVs for such applications has not been fully exploited yet. Considering the vast variety of cells that can be involved in an infection, vesicle-based analytical methods are just emerging and the number of reported applications is still relatively small. Aim of this review is to discuss the current state of the art of EV-based assays, especially in the context of antimicrobial research and therapy, and to present some new perspectives for a more exhaustive and creative exploration in the future.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAntibioticsen_US
dc.subjectAntimicrobial drugsen_US
dc.subjectAntiviral drugsen_US
dc.subjectApoptotic bodiesen_US
dc.subjectBacterial bioavailabilityen_US
dc.subjectExosomesen_US
dc.subjectIn vitroen_US
dc.subjectMembrane permeabilityen_US
dc.subjectMicrovesiclesen_US
dc.subjectOuter membrane vesiclesen_US
dc.titleExtracellular vesicles as novel assay tools to study cellular interactions of anti-infective compounds - A perspective.en_US
dc.typeReviewen_US
dc.identifier.eissn1872-8294
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalAdvanced drug delivery reviewsen_US
dc.source.volume173
dc.source.beginpage492
dc.source.endpage503
dc.source.journaltitleAdvanced drug delivery reviews
dc.source.countryNetherlands


Files in this item

Thumbnail
Name:
Publisher version
Thumbnail
Name:
Richter and Lehr.pdf
Embargo:
2022-03-26
Size:
6.036Mb
Format:
PDF
Description:
accepted manuscript

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International