Show simple item record

dc.contributor.authorBusse, Mandy
dc.contributor.authorPlenagl, Susanne
dc.contributor.authorCampe, Norina Kim Jutta
dc.contributor.authorMüller, Andreas J
dc.contributor.authorTedford, Kerry
dc.contributor.authorSchumacher, Anne
dc.contributor.authorZenclussen, Ana Claudia
dc.date.accessioned2021-12-01T13:05:41Z
dc.date.available2021-12-01T13:05:41Z
dc.date.issued2021-10-08
dc.identifier.citationCells. 2021 Oct 8;10(10):2693. doi: 10.3390/cells10102693.en_US
dc.identifier.pmid34685673
dc.identifier.doi10.3390/cells10102693
dc.identifier.urihttp://hdl.handle.net/10033/623106
dc.description.abstractImmunological networks balance tolerance towards paternal alloantigens during pregnancy with normal immune response to pathogens. Subclinical infections can impact this balance and lead to preterm birth or even intrauterine fetal death (IUFD). We recently showed that loss of maternal B cells renders murine fetuses susceptible to IUFD after LPS exposure. Since the signaling pathway involved in this B-cell mediated response remains unclear, we aimed to understand the participation of MyD88 in this response using B-cell-specific MyD88-deficient (BMyD88-/-) mice. B cells isolated from wild-type (WT), BMyD88-/-, CD19-/- and MyD88-/- dams on gestational day (gd) 10 responded differently to LPS concerning cytokine secretion. In vivo LPS challenge on gd 10 provoked IUFD in CD19-/- mothers with functional MyD88, while fetuses from BMyD88-/- and MyD88-/- mice were protected. These outcomes were associated with altered cytokine levels in the maternal serum and changes in CD4+ T-cell responses. Overall, the loss of MyD88 signaling in maternal B cells prevents the activation of cytokine release that leads to IUFD. Thus, while MyD88 signaling in maternal B cells protects the mother from infection, it ultimately kills the fetus. Understanding the cellular mechanisms underlying infection-driven pregnancy complications is the first step to designing powerful therapeutic strategies in the future.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectB cellsen_US
dc.subjectinflammationen_US
dc.subjectintrauterine fetal deathen_US
dc.subjectpregnancyen_US
dc.titleMaternal B Cell-Intrinsic MyD88 Signaling Mediates LPS-Driven Intrauterine Fetal Death.en_US
dc.typeArticleen_US
dc.identifier.eissn2073-4409
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalCellsen_US
dc.source.volume10
dc.source.issue10
refterms.dateFOA2021-12-01T13:05:42Z
dc.source.journaltitleCells
dc.source.countrySwitzerland


Files in this item

Thumbnail
Name:
Busse et al.pdf
Size:
1.759Mb
Format:
PDF
Description:
Open Access publication

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International