Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells.
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Authors
Formaglio, PaulineAlabdullah, Mohamad
Siokis, Anastasios
Handschuh, Juliane
Sauerland, Ina
Fu, Yan
Krone, Anna
Gintschel, Patricia
Stettin, Juliane
Heyde, Sandrina
Mohr, Juliane
Philipsen, Lars
Schröder, Anja
Robert, Philippe A
Zhao, Gang
Khailaie, Sahamoddin
Dudeck, Anne
Bertrand, Jessica
Späth, Gerald F
Kahlfuß, Sascha
Bousso, Philippe
Schraven, Burkhart
Huehn, Jochen
Binder, Sebastian
Meyer-Hermann, Michael
Müller, Andreas J
Issue Date
2021-10-15
Metadata
Show full item recordAbstract
Nitric oxide (NO) is an important antimicrobial effector but also prevents unnecessary tissue damage by shutting down the recruitment of monocyte-derived phagocytes. Intracellular pathogens such as Leishmania major can hijack these cells as a niche for replication. Thus, NO might exert containment by restricting the availability of the cellular niche required for efficient pathogen proliferation. However, such indirect modes of action remain to be established. By combining mathematical modeling with intravital 2-photon biosensors of pathogen viability and proliferation, we show that low L. major proliferation results not from direct NO impact on the pathogen but from reduced availability of proliferation-permissive host cells. Although inhibiting NO production increases recruitment of these cells, and thus pathogen proliferation, blocking cell recruitment uncouples the NO effect from pathogen proliferation. Therefore, NO fulfills two distinct functions for L. major containment: permitting direct killing and restricting the supply of proliferation-permissive host cells.Citation
mmunity. 2021 Oct 15:S1074-7613(21)00406-4. doi: 10.1016/j.immuni.2021.09.021. Epub ahead of print.Affiliation
BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56, 38106 Braunschweig, Germany.Publisher
Cell PressJournal
ImmunityPubMed ID
34687607Type
ArticleLanguage
enEISSN
1097-4180ae974a485f413a2113503eed53cd6c53
10.1016/j.immuni.2021.09.021
Scopus Count
The following license files are associated with this item:
- Creative Commons
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