IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis.
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van der Heijden, Wouter
Dos Santos, Jéssica Cristina
Swertz, Morris A
van der Ven, Andre
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AbstractThe analysis resulted in one significant association with CA HIV-1 DNA (rs2613996, P < 5 × 10-8) and two suggestive associations with RNA:DNA ratio (rs7113204 and rs7817589, P < 5 × 10-7). Then, we prioritized PTDSS2, IRF7, RNH1, and DEAF1 as potential HIV-1 reservoir modifiers and validated that higher expressions of IRF7 and RNH1 were accompanied by rs7113204-G. Moreover, RNA:DNA ratio, indicating relative HIV-1 transcription activity, was lower in PLHIV carrying this variant.
CitationBMC Med. 2021 Nov 16;19(1):282. doi: 10.1186/s12916-021-02156-5.
AffiliationCiiM, Zentrum für Individualisierte Infektionsmedizin, c/o TWINCORE, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
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