IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis.
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Authors
Zhang, ZhenhuaTrypsteen, Wim
Blaauw, Marc
Chu, Xiaojing
Rutsaert, Sofie
Vandekerckhove, Linos
van der Heijden, Wouter
Dos Santos, Jéssica Cristina
Xu, Cheng-Jian
Swertz, Morris A
van der Ven, Andre
Li, Yang
Issue Date
2021-11-16
Metadata
Show full item recordAbstract
The analysis resulted in one significant association with CA HIV-1 DNA (rs2613996, P < 5 × 10-8) and two suggestive associations with RNA:DNA ratio (rs7113204 and rs7817589, P < 5 × 10-7). Then, we prioritized PTDSS2, IRF7, RNH1, and DEAF1 as potential HIV-1 reservoir modifiers and validated that higher expressions of IRF7 and RNH1 were accompanied by rs7113204-G. Moreover, RNA:DNA ratio, indicating relative HIV-1 transcription activity, was lower in PLHIV carrying this variant.Citation
BMC Med. 2021 Nov 16;19(1):282. doi: 10.1186/s12916-021-02156-5.Affiliation
CiiM, Zentrum für Individualisierte Infektionsmedizin, c/o TWINCORE, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.Publisher
BMCJournal
BMC medicinePubMed ID
34781942Type
ArticleLanguage
enEISSN
1741-7015ae974a485f413a2113503eed53cd6c53
10.1186/s12916-021-02156-5
Scopus Count
The following license files are associated with this item:
- Creative Commons
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