IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis.

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Authors
Zhang, Zhenhua
Trypsteen, Wim
Blaauw, Marc
Chu, Xiaojing
Rutsaert, Sofie
Vandekerckhove, Linos
van der Heijden, Wouter
Dos Santos, Jéssica Cristina
Xu, Cheng-Jian
Swertz, Morris A
Issue Date
2021-11-16

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Abstract
The analysis resulted in one significant association with CA HIV-1 DNA (rs2613996, P < 5 × 10-8) and two suggestive associations with RNA:DNA ratio (rs7113204 and rs7817589, P < 5 × 10-7). Then, we prioritized PTDSS2, IRF7, RNH1, and DEAF1 as potential HIV-1 reservoir modifiers and validated that higher expressions of IRF7 and RNH1 were accompanied by rs7113204-G. Moreover, RNA:DNA ratio, indicating relative HIV-1 transcription activity, was lower in PLHIV carrying this variant.
Citation
BMC Med. 2021 Nov 16;19(1):282. doi: 10.1186/s12916-021-02156-5.
Affiliation
CiiM, Zentrum für Individualisierte Infektionsmedizin, c/o TWINCORE, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Publisher
BMC
Journal
BMC medicine
URI
http://hdl.handle.net/10033/623123
DOI
10.1186/s12916-021-02156-5
PubMed ID
34781942
Type
Article
Language
en
EISSN
1741-7015
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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International