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IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis.

dc.contributor.authorZhang, Zhenhua
dc.contributor.authorTrypsteen, Wim
dc.contributor.authorBlaauw, Marc
dc.contributor.authorChu, Xiaojing
dc.contributor.authorRutsaert, Sofie
dc.contributor.authorVandekerckhove, Linos
dc.contributor.authorvan der Heijden, Wouter
dc.contributor.authorDos Santos, Jéssica Cristina
dc.contributor.authorXu, Cheng-Jian
dc.contributor.authorSwertz, Morris A
dc.contributor.authorvan der Ven, Andre
dc.contributor.authorLi, Yang
dc.date.accessioned2021-12-20T11:34:12Z
dc.date.available2021-12-20T11:34:12Z
dc.date.issued2021-11-16
dc.identifier.citationBMC Med. 2021 Nov 16;19(1):282. doi: 10.1186/s12916-021-02156-5.en_US
dc.identifier.pmid34781942
dc.identifier.doi10.1186/s12916-021-02156-5
dc.identifier.urihttp://hdl.handle.net/10033/623123
dc.description.abstractThe analysis resulted in one significant association with CA HIV-1 DNA (rs2613996, P < 5 × 10-8) and two suggestive associations with RNA:DNA ratio (rs7113204 and rs7817589, P < 5 × 10-7). Then, we prioritized PTDSS2, IRF7, RNH1, and DEAF1 as potential HIV-1 reservoir modifiers and validated that higher expressions of IRF7 and RNH1 were accompanied by rs7113204-G. Moreover, RNA:DNA ratio, indicating relative HIV-1 transcription activity, was lower in PLHIV carrying this variant.en_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCell-associated HIV-1 DNAen_US
dc.subjectCell-associated HIV-1 RNAen_US
dc.subjectGenetic variantsen_US
dc.subjectHIVen_US
dc.subjectQuantitative trait locusen_US
dc.titleIRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis.en_US
dc.typeArticleen_US
dc.identifier.eissn1741-7015
dc.contributor.departmentCiiM, Zentrum für Individualisierte Infektionsmedizin, c/o TWINCORE, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalBMC medicineen_US
dc.source.volume19
dc.source.issue1
dc.source.beginpage282
dc.source.endpage
refterms.dateFOA2021-12-20T11:34:13Z
dc.source.journaltitleBMC medicine
dc.source.countryEngland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International