Show simple item record

dc.contributor.authorOlbrich, Laura
dc.contributor.authorStockdale, Lisa
dc.contributor.authorBasu Roy, Robindra
dc.contributor.authorSong, Rinn
dc.contributor.authorCicin-Sain, Luka
dc.contributor.authorWhittaker, Elizabeth
dc.contributor.authorPrendergast, Andrew J
dc.contributor.authorFletcher, Helen
dc.contributor.authorSeddon, James A
dc.date.accessioned2022-01-06T16:15:03Z
dc.date.available2022-01-06T16:15:03Z
dc.date.issued2021-12-09
dc.identifier.citationPLoS Pathog. 2021 Dec 9;17(12):e1010061. doi: 10.1371/journal.ppat.1010061.en_US
dc.identifier.pmid34882748
dc.identifier.doi10.1371/journal.ppat.1010061
dc.identifier.urihttp://hdl.handle.net/10033/623128
dc.description.abstractOver 1 million children develop tuberculosis (TB) each year, with a quarter dying. Multiple factors impact the risk of a child being exposed to Mycobacterium tuberculosis (Mtb), the risk of progressing to TB disease, and the risk of dying. However, an emerging body of evidence suggests that coinfection with cytomegalovirus (CMV), a ubiquitous herpes virus, impacts the host response to Mtb, potentially influencing the probability of disease progression, type of TB disease, performance of TB diagnostics, and disease outcome. It is also likely that infection with Mtb impacts CMV pathogenesis. Our current understanding of the burden of these 2 diseases in children, their immunological interactions, and the clinical consequence of coinfection is incomplete. It is also unclear how potential interventions might affect disease progression and outcome for TB or CMV. This article reviews the epidemiological, clinical, and immunological literature on CMV and TB in children and explores how the 2 pathogens interact, while also considering the impact of HIV on this relationship. It outlines areas of research uncertainty and makes practical suggestions as to potential studies that might address these gaps. Current research is hampered by inconsistent definitions, study designs, and laboratory practices, and more consistency and collaboration between researchers would lead to greater clarity. The ambitious targets outlined in the World Health Organization End TB Strategy will only be met through a better understanding of all aspects of child TB, including the substantial impact of coinfections.en_US
dc.language.isoenen_US
dc.publisherPLOSen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleUnderstanding the interaction between cytomegalovirus and tuberculosis in children: The way forward.en_US
dc.typeReviewen_US
dc.identifier.eissn1553-7374
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalPLoS pathogensen_US
dc.source.volume17
dc.source.issue12
dc.source.beginpagee1010061
dc.source.endpage
refterms.dateFOA2022-01-06T16:15:03Z
dc.source.journaltitlePLoS pathogens
dc.source.countryUnited States


Files in this item

Thumbnail
Name:
Olbrich et al.pdf
Size:
1.504Mb
Format:
PDF
Description:
Open Access publication

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International