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dc.contributor.authorFaisal, Muhammad R
dc.contributor.authorKellermann, Matthias Y
dc.contributor.authorRohde, Sven
dc.contributor.authorPutra, Masteria Y
dc.contributor.authorMurniasih, Tutik
dc.contributor.authorRisdian, Chandra
dc.contributor.authorMohr, Kathrin I
dc.contributor.authorWink, Joachim
dc.contributor.authorPraditya, Dimas F
dc.contributor.authorSteinmann, Eike
dc.contributor.authorKöck, Matthias
dc.contributor.authorSchupp, Peter J
dc.date.accessioned2022-01-14T12:49:18Z
dc.date.available2022-01-14T12:49:18Z
dc.date.issued2021-10-27
dc.identifier.citationMar Drugs. 2021 Oct 27;19(11):611. doi: 10.3390/md19110611.en_US
dc.identifier.pmid34822482
dc.identifier.doi10.3390/md19110611
dc.identifier.urihttp://hdl.handle.net/10033/623143
dc.description.abstractTwo known Polybrominated Diphenyl Ethers (PBDEs), 3,4,5-tribromo-2-(2',4'-dibromophenoxy)phenol (1d) and 3,4,5,6-tetrabromo-2-(2',4'-dibromophenoxy)phenol (2b), were isolated from the Indonesian marine sponge Lamellodysidea herbacea. The structure was confirmed using 13C chemical shift average deviation and was compared to the predicted structures and recorded chemical shifts in previous studies. We found a wide range of bioactivities from the organic crude extract, such as (1) a strong deterrence against the generalist pufferfish Canthigaster solandri, (2) potent inhibition against environmental and human pathogenic bacterial and fungal strains, and (3) the inhibition of the Hepatitis C Virus (HCV). The addition of a bromine atom into the A-ring of compound 2b resulted in higher fish feeding deterrence compared to compound 1d. On the contrary, compound 2b showed only more potent inhibition against the Gram-negative bacteria Rhodotorula glutinis (MIC 2.1 μg/mL), while compound 1d showed more powerful inhibition against the other human pathogenic bacteria and fungi. The first report of a chemical defense by compounds 1d and 2b against fish feeding and environmental relevant bacteria, especially pathogenic bacteria, might be one reason for the widespread occurrence of the shallow water sponge Lamellodysidea herbacea in Indonesia and the Indo-Pacific.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPBDEsen_US
dc.subjectantifungalen_US
dc.subjectchemical defenseen_US
dc.subjectdemospongiaeen_US
dc.subjectinhibitoryen_US
dc.subjectpalatabilityen_US
dc.titleEcological and pharmacological activities of polybrominated diphenyl ethers (Pbdes) from the indonesian marine sponge lamellodysidea herbacea.en-US
dc.typeArticleen_US
dc.identifier.eissn1660-3397
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalMarine drugsen_US
dc.source.volume19
dc.source.issue11
dc.source.journaltitleMarine drugs
dc.source.countrySwitzerland


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Except where otherwise noted, this item's license is described as Attribution 4.0 International