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dc.contributor.authorTsalik, Ephraim L
dc.contributor.authorFiorino, Cassandra
dc.contributor.authorAqeel, Ammara
dc.contributor.authorLiu, Yiling
dc.contributor.authorHenao, Ricardo
dc.contributor.authorKo, Emily R
dc.contributor.authorBurke, Thomas W
dc.contributor.authorReller, Megan E
dc.contributor.authorBodinayake, Champica K
dc.contributor.authorNagahawatte, Ajith
dc.contributor.authorArachchi, Wasantha K
dc.contributor.authorDevasiri, Vasantha
dc.contributor.authorKurukulasooriya, Ruvini
dc.contributor.authorMcClain, Micah T
dc.contributor.authorWoods, Christopher W
dc.contributor.authorGinsburg, Geoffrey S
dc.contributor.authorTillekeratne, L Gayani
dc.contributor.authorSchughart, Klaus
dc.date.accessioned2022-01-14T14:25:12Z
dc.date.available2022-01-14T14:25:12Z
dc.date.issued2021-10-27
dc.identifier.citationFront Immunol. 2021 Oct 27;12:741837. doi: 10.3389/fimmu.2021.741837.en_US
dc.identifier.pmid34777354
dc.identifier.doi10.3389/fimmu.2021.741837
dc.identifier.urihttp://hdl.handle.net/10033/623144
dc.description.abstractViruses cause a wide spectrum of clinical disease, the majority being acute respiratory infections (ARI). In most cases, ARI symptoms are similar for different viruses although severity can be variable. The objective of this study was to understand the shared and unique elements of the host transcriptional response to different viral pathogens. We identified 162 subjects in the US and Sri Lanka with infections due to influenza, enterovirus/rhinovirus, human metapneumovirus, dengue virus, cytomegalovirus, Epstein Barr Virus, or adenovirus. Our dataset allowed us to identify common pathways at the molecular level as well as virus-specific differences in the host immune response. Conserved elements of the host response to these viral infections highlighted the importance of interferon pathway activation. However, the magnitude of the responses varied between pathogens. We also identified virus-specific responses to influenza, enterovirus/rhinovirus, and dengue infections. Influenza-specific differentially expressed genes (DEG) revealed up-regulation of pathways related to viral defense and down-regulation of pathways related to T cell and neutrophil responses. Functional analysis of entero/rhinovirus-specific DEGs revealed up-regulation of pathways for neutrophil activation, negative regulation of immune response, and p38MAPK cascade and down-regulation of virus defenses and complement activation. Functional analysis of dengue-specific up-regulated DEGs showed enrichment of pathways for DNA replication and cell division whereas down-regulated DEGs were mainly associated with erythrocyte and myeloid cell homeostasis, reactive oxygen and peroxide metabolic processes. In conclusion, our study will contribute to a better understanding of molecular mechanisms to viral infections in humans and the identification of biomarkers to distinguish different types of viral infections.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectdengue virus (DEN)en_US
dc.subjectenterovirusen_US
dc.subjecthost response (HR)en_US
dc.subjecthuman patientsen_US
dc.subjectinfluenzaen_US
dc.subjectmetapneumovirusen_US
dc.subjectrhinovirus (RV)en_US
dc.subjectviral respiratory infectionsen_US
dc.titleThe Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood.en_US
dc.typeArticleen_US
dc.identifier.eissn1664-3224
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalFrontiers in immunologyen_US
dc.source.volume12
dc.source.beginpage741837
dc.source.endpage
refterms.dateFOA2022-01-14T14:25:12Z
dc.source.journaltitleFrontiers in immunology
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countrySwitzerland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International