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dc.contributor.authorLaudenbach, Beatrice T
dc.contributor.authorKrey, Karsten
dc.contributor.authorEmslander, Quirin
dc.contributor.authorAndersen, Line Lykke
dc.contributor.authorReim, Alexander
dc.contributor.authorScaturro, Pietro
dc.contributor.authorMundigl, Sarah
dc.contributor.authorDächert, Christopher
dc.contributor.authorManske, Katrin
dc.contributor.authorMoser, Markus
dc.contributor.authorLudwig, Janos
dc.contributor.authorWohlleber, Dirk
dc.contributor.authorKröger, Andrea
dc.contributor.authorBinder, Marco
dc.contributor.authorPichlmair, Andreas
dc.date.accessioned2022-01-21T16:27:58Z
dc.date.available2022-01-21T16:27:58Z
dc.date.issued2021-11-25
dc.identifier.citationNat Commun. 2021 Nov 25;12(1):6918. doi: 10.1038/s41467-021-27239-y.en_US
dc.identifier.pmid34824277
dc.identifier.doi10.1038/s41467-021-27239-y
dc.identifier.urihttp://hdl.handle.net/10033/623151
dc.description.abstractWhile viral replication processes are largely understood, comparably little is known on cellular mechanisms degrading viral RNA. Some viral RNAs bear a 5'-triphosphate (PPP-) group that impairs degradation by the canonical 5'-3' degradation pathway. Here we show that the Nudix hydrolase 2 (NUDT2) trims viral PPP-RNA into monophosphorylated (P)-RNA, which serves as a substrate for the 5'-3' exonuclease XRN1. NUDT2 removes 5'-phosphates from PPP-RNA in an RNA sequence- and overhang-independent manner and its ablation in cells increases growth of PPP-RNA viruses, suggesting an involvement in antiviral immunity. NUDT2 is highly homologous to bacterial RNA pyrophosphatase H (RppH), a protein involved in the metabolism of bacterial mRNA, which is 5'-tri- or diphosphorylated. Our results show a conserved function between bacterial RppH and mammalian NUDT2, indicating that the function may have adapted from a protein responsible for RNA turnover in bacteria into a protein involved in the immune defense in mammals.en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleNUDT2 initiates viral RNA degradation by removal of 5'-phosphates.en_US
dc.typeArticleen_US
dc.identifier.eissn2041-1723
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalNature communicationsen_US
dc.source.volume12
dc.source.issue1
dc.source.beginpage6918
dc.source.endpage
refterms.dateFOA2022-01-21T16:27:58Z
dc.source.journaltitleNature communications
dc.source.countryEngland


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