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dc.contributor.authorWendisch, Daniel
dc.contributor.authorDietrich, Oliver
dc.contributor.authorMari, Tommaso
dc.contributor.authorvon Stillfried, Saskia
dc.contributor.authorIbarra, Ignacio L
dc.contributor.authorMittermaier, Mirja
dc.contributor.authorMache, Christin
dc.contributor.authorChua, Robert Lorenz
dc.contributor.authorKnoll, Rainer
dc.contributor.authorTimm, Sara
dc.contributor.authorBrumhard, Sophia
dc.contributor.authorKrammer, Tobias
dc.contributor.authorZauber, Henrik
dc.contributor.authorHiller, Anna Luisa
dc.contributor.authorPascual-Reguant, Anna
dc.contributor.authorMothes, Ronja
dc.contributor.authorBülow, Roman David
dc.contributor.authorSchulze, Jessica
dc.contributor.authorLeipold, Alexander M
dc.contributor.authorDjudjaj, Sonja
dc.contributor.authorErhard, Florian
dc.contributor.authorGeffers, Robert
dc.contributor.authorPott, Fabian
dc.contributor.authorKazmierski, Julia
dc.contributor.authorRadke, Josefine
dc.contributor.authorPergantis, Panagiotis
dc.contributor.authorBaßler, Kevin
dc.contributor.authorConrad, Claudia
dc.contributor.authorAschenbrenner, Anna C
dc.contributor.authorSawitzki, Birgit
dc.contributor.authorLandthaler, Markus
dc.contributor.authorWyler, Emanuel
dc.contributor.authorHorst, David
dc.contributor.authorHippenstiel, Stefan
dc.contributor.authorHocke, Andreas
dc.contributor.authorHeppner, Frank L
dc.contributor.authorUhrig, Alexander
dc.contributor.authorGarcia, Carmen
dc.contributor.authorMachleidt, Felix
dc.contributor.authorHerold, Susanne
dc.contributor.authorElezkurtaj, Sefer
dc.contributor.authorThibeault, Charlotte
dc.contributor.authorWitzenrath, Martin
dc.contributor.authorCochain, Clément
dc.contributor.authorSuttorp, Norbert
dc.contributor.authorDrosten, Christian
dc.contributor.authorGoffinet, Christine
dc.contributor.authorKurth, Florian
dc.contributor.authorSchultze, Joachim L
dc.contributor.authorRadbruch, Helena
dc.contributor.authorOchs, Matthias
dc.contributor.authorEils, Roland
dc.contributor.authorMüller-Redetzky, Holger
dc.contributor.authorHauser, Anja E
dc.contributor.authorLuecken, Malte D
dc.contributor.authorTheis, Fabian J
dc.contributor.authorConrad, Christian
dc.contributor.authorWolff, Thorsten
dc.contributor.authorBoor, Peter
dc.contributor.authorSelbach, Matthias
dc.contributor.authorSaliba, Antoine-Emmanuel
dc.contributor.authorSander, Leif Erik
dc.date.accessioned2022-02-03T13:24:47Z
dc.date.available2022-02-03T13:24:47Z
dc.date.issued2021-11-27
dc.identifier.citationCell. 2021 Dec 22;184(26):6243-6261.e27. doi: 10.1016/j.cell.2021.11.033. Epub 2021 Nov 27. PMID: 34914922.en_US
dc.identifier.pmid34914922
dc.identifier.doi10.1016/j.cell.2021.11.033
dc.identifier.urihttp://hdl.handle.net/10033/623157
dc.description.abstractCOVID-19-induced "acute respiratory distress syndrome" (ARDS) is associated with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury remains incompletely understood. Here, we analyze pulmonary immune responses and lung pathology in two cohorts of patients with COVID-19 ARDS using functional single-cell genomics, immunohistology, and electron microscopy. We describe an accumulation of CD163-expressing monocyte-derived macrophages that acquired a profibrotic transcriptional phenotype during COVID-19 ARDS. Gene set enrichment and computational data integration revealed a significant similarity between COVID-19-associated macrophages and profibrotic macrophage populations identified in idiopathic pulmonary fibrosis. COVID-19 ARDS was associated with clinical, radiographic, histopathological, and ultrastructural hallmarks of pulmonary fibrosis. Exposure of human monocytes to SARS-CoV-2, but not influenza A virus or viral RNA analogs, was sufficient to induce a similar profibrotic phenotype in vitro. In conclusion, we demonstrate that SARS-CoV-2 triggers profibrotic macrophage responses and pronounced fibroproliferative ARDS.en_US
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectARDSen_US
dc.subjectCOVID-19en_US
dc.subjectIPFen_US
dc.subjectSARS-CoV-2en_US
dc.subjectfibrosisen_US
dc.subjectlungen_US
dc.subjectmacrophagesen_US
dc.subjectmonocytesen_US
dc.subjectproteomicsen_US
dc.subjectpulmonary fibrosisen_US
dc.subjectsingle-cell transcriptomicsen_US
dc.titleSARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.en_US
dc.typeArticleen_US
dc.identifier.eissn1097-4172
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalCellen_US
dc.source.volume184
dc.source.issue26
dc.source.beginpage6243
dc.source.endpage6261.e27
refterms.dateFOA2022-02-03T13:24:47Z
dc.source.journaltitleCell
dc.source.countryUnited States


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