Symptom Burden and Factors Associated with Acute Respiratory Infections in the First Two Years of Life-Results from the LoewenKIDS Cohort.
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Authors
Langer, SusanHorn, Johannes
Gottschick, Cornelia
Klee, Bianca
Purschke, Oliver
Caputo, Mahrrouz
Dorendorf, Evelyn
Meyer-Schlinkmann, Kristin Maria
Raupach-Rosin, Heike
Karch, André
Rübsamen, Nicole
Aydogdu, Mustafa
Buhles, Matthias
Dressler, Frank
Eberl, Wolfgang
Koch, Franz Edler von
Frambach, Torsten
Franz, Heiko
Guthmann, Florian
Guzman, Carlos A
Haase, Roland
Hansen, Gesine
Heselich, Valerie
Hübner, Johannes
Koch, Hans Georg
Oberhoff, Carsten
Riese, Peggy

Schild, Ralf
Seeger, Sven
Tchirikov, Michael
Trittel, Stephanie
von Kaisenberg, Constantin
Mikolajczyk, Rafael
Issue Date
2022-01-05
Metadata
Show full item recordAbstract
Acute respiratory infections (ARIs) are the most common childhood illnesses worldwide whereby the reported frequency varies widely, often depending on type of assessment. Symptom diaries are a powerful tool to counteract possible under-reporting, particularly of milder infections, and thus offer the possibility to assess the full burden of ARIs. The following analyses are based on symptom diaries from participants of the German birth cohort study LoewenKIDS. Primary analyses included frequencies of ARIs and specific symptoms. Factors, which might be associated with an increased number of ARIs, were identified using the Poisson regression. A subsample of two hundred eighty-eight participants were included. On average, 13.7 ARIs (SD: 5.2 median: 14.0 IQR: 10-17) were reported in the first two years of life with an average duration of 11 days per episode (SD: 5.8, median: 9.7, IQR: 7-14). The median age for the first ARI episode was 91 days (IQR: 57-128, mean: 107, SD: 84.5). Childcare attendance and having siblings were associated with an increased frequency of ARIs, while exclusive breastfeeding for the first three months was associated with less ARIs, compared to exclusive breastfeeding for a longer period. This study provides detailed insight into the symptom burden of ARIs in German infants.Citation
Microorganisms. 2022 Jan 5;10(1):111. doi: 10.3390/microorganisms10010111.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
MDPIJournal
MicroorganismsPubMed ID
35056559Type
ArticleLanguage
enISSN
2076-2607ae974a485f413a2113503eed53cd6c53
10.3390/microorganisms10010111
Scopus Count
The following license files are associated with this item:
- Creative Commons
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