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dc.contributor.authorHug, Joachim J
dc.contributor.authorKjaerulff, Louise
dc.contributor.authorGarcia, Ronald
dc.contributor.authorMüller, Rolf
dc.date.accessioned2022-02-15T10:56:10Z
dc.date.available2022-02-15T10:56:10Z
dc.date.issued2022-01-14
dc.identifier.citationMar Drugs. 2022 Jan 14;20(1):72. doi: 10.3390/md20010072.en_US
dc.identifier.pmid35049927
dc.identifier.doi10.3390/md20010072
dc.identifier.urihttp://hdl.handle.net/10033/623166
dc.description.abstractMarine myxobacteria present a virtually unexploited reservoir for the discovery of natural products with diverse biological functions and novel chemical scaffolds. We report here the isolation and structure elucidation of eight new deoxyenhygrolides (1-8) from the marine myxobacterium Plesiocystis pacifica DSM 14875T. The herein described deoxyenhygrolides C-J (1-8) feature a butenolide core with an ethyl residue at C-3 of the γ-lactone in contrast to the previously described derivatives, deoxyenhygrolides A and B, which feature an isobutyl residue at this position. The butenolide core is 2,4-substituted with a benzyl (1, 2 and 7), benzoyl (3 and 4) or benzyl alcohol (5, 6 and 8) moiety in the 2-position and a benzylidene (1-6) or benzylic hemiketal (7 and 8) in the 4-position. The description of these new deoxyenhygrolide derivatives, alongside genomic in silico investigation regarding putative biosynthetic genes, provides some new puzzle pieces on how this natural product class might be formed by marine myxobacteria.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPlesiocystis pacificaen_US
dc.subjectbutenolideen_US
dc.subjectdeoxyenhygrolidesen_US
dc.subjectenhygrolidesen_US
dc.subjectfuranolideen_US
dc.subjectmyxobacteriaen_US
dc.subjectnatural productsen_US
dc.titleNew Deoxyenhygrolides from Provide Insights into Butenolide Core Biosynthesis.en_US
dc.typeArticleen_US
dc.identifier.eissn1660-3397
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalMarine drugsen_US
dc.source.volume20
dc.source.issue1
refterms.dateFOA2022-02-15T10:56:11Z
dc.source.journaltitleMarine drugs
dc.source.countrySwitzerland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International