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dc.contributor.authorSeffer, Malin-Theres
dc.contributor.authorEden, Gabriele
dc.contributor.authorEngelmann, Susanne
dc.contributor.authorKielstein, Jan T
dc.date.accessioned2022-05-06T14:04:51Z
dc.date.available2022-05-06T14:04:51Z
dc.date.issued2020-08-24
dc.date.submitted2022-05-06
dc.identifier.pmid32843409
dc.identifier.doi10.1136/bcr-2020-235262
dc.identifier.urihttp://hdl.handle.net/10033/623189
dc.description.abstractRemoval of bacteria from the blood by means of extracorporeal techniques has been attempted for decades. In late 2019, the European Union licensed the first ever haemoperfusion device for removal of bacteria from the blood. The active ingredient of Seraph 100 Microbind Affinity Blood Filter is ultrahigh molecular weight polyethylene beads with endpoint-attached heparin. Bacteria have been shown to bind to heparin as they would usually do to the heparan sulfate on the cell surface, thereby being removed from the blood stream. We describe the first case of a female chronic haemodialysis patient in which this device was clinically used for a Staphylococcus aureus infection that persisted for 4 days despite antibiotic therapy. After a single treatment, the bacterial load decreased and the blood cultures at the end of a 4 hour haemoperfusion exhibited no bacterial growth.en_US
dc.language.isoenen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectdialysisen_US
dc.subjectdrugs: infectious diseasesen_US
dc.subjectinfectionsen_US
dc.subjecttherapeutic indicationsen_US
dc.titleElimination of Staphylococcus aureus from the bloodstream using a novel biomimetic sorbent haemoperfusion device.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn1757-790X
dc.identifier.journalBMJ case reportsen_US
dc.source.volume13
dc.source.issue8
refterms.dateFOA2022-05-06T14:04:51Z
dc.source.journaltitleBMJ case reports
dc.source.countryEngland


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International