Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression.
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Authors
Brandt, SabineBallhause, Tobias M
Bernhardt, Anja
Becker, Annika
Salaru, Delia
Le-Deffge, Hien Minh
Fehr, Alexander
Fu, Yan
Philipsen, Lars
Djudjaj, Sonja
Müller, Andreas J
Kramann, Rafael
Ibrahim, Mahmoud
Geffers, Robert
Siebel, Chris
Isermann, Berend
Heidel, Florian H
Lindquist, Jonathan A
Mertens, Peter R
Issue Date
2020-08-28Submitted date
2019-12-13
Metadata
Show full item recordAbstract
Kidney injuries that result in chronic inflammation initiate crosstalk between stressed resident cells and infiltrating immune cells. In animal models, whole-body receptor Notch3 deficiency protects from leukocyte infiltration and organ fibrosis. However, the relative contribution of Notch3 expression in tissue versus infiltrating immune cells is unknown.PubMed ID
32859670Type
ArticleLanguage
enEISSN
1533-3450ae974a485f413a2113503eed53cd6c53
10.1681/ASN.2019121289
Scopus Count
The following license files are associated with this item:
- Creative Commons
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