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Issue Date
2020-08-24Submitted date
2020-07-22
Metadata
Show full item recordAbstract
Contiguous quaternary carbons in terpene natural products remain a major challenge in total synthesis. Synthetic strategies to overcome this challenge will be a pivotal prerequisite to the medicinal application of natural products and their analogs or derivatives. In this review, we cover syntheses of natural products that exhibit a dense assembly of quaternary carbons and whose syntheses were uncompleted until recently. While discussing their syntheses, we not only cover the most recent total syntheses but also provide an update on the status quo of modern syntheses of complex natural products. Herein, we review (±)-canataxpropellane, (+)-waihoensene, (-)-illisimonin A and (±)-11-O-debenzoyltashironin as prominent examples of natural products bearing contiguous quaternary carbons.Journal
Molecules (Basel, Switzerland)PubMed ID
32847075Type
ArticleLanguage
enEISSN
1420-3049ae974a485f413a2113503eed53cd6c53
10.3390/molecules25173841
Scopus Count
The following license files are associated with this item:
- Creative Commons