Associations between gut microbiota and genetic risk for rheumatoid arthritis in the absence of disease: a cross-sectional study.

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Authors
Wells, Philippa M
Adebayo, Adewale S
Bowyer, Ruth C E
Freidin, Maxim B
Finckh, Axel
Strowig, Till
Lesker, Till Robin
Alpizar-Rodriguez, Deshire
Gilbert, Benoit
Kirkham, Bruce
Issue Date
2020-06-25

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Abstract
We found that presence of Prevotella spp were positively associated with the rheumatoid arthritis PRS in TwinsUK participants (q<1 × 10-7). This finding was validated in SCREEN-RA participants (n=133) carrying established shared epitope risk alleles (q=0·0011). We also found an association between Prevotella spp and presence of preclinical rheumatoid arthritis phases (q=0·021).
Journal
The Lancet. Rheumatology
URI
http://hdl.handle.net/10033/623248
DOI
10.1016/S2665-9913(20)30064-3
PubMed ID
33345197
Type
Article
Language
en
EISSN
2665-9913
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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International